Eckhart Sindern

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Eckhart Sindern (* 1960 in Kiel ) is a German neurologist , professor and chief physician for neurology at the Diakovere Friederikenstift Hannover. Sindern is known for his work in the field of multiple sclerosis , Guillain-Barré syndrome and adult polyglucosan body disease .

Life

Sindern was approved as a doctor in 1986 at the University of Lübeck and received a Dr. med. PhD in Lübeck. His dissertation dealt with the immunological aspects of epilepsy . From 1987 to 1992 he was a research assistant at the Hannover Medical School . In 1992 he was certified as a neurologist in Hanover. In the same year he was appointed senior physician at the Bergmannsheil University Neurological Clinic in Bochum. In 1998 he completed his habilitation on "Cell Activation Mechanisms in Blood and Liquor in Acute Guillain Barrè Syndrome and Multiple Sclerosis" and became head of the clinical neuroimmunology and experimental CSF diagnostics department at the Bergmannsheil University Hospital and spokesman for the Multiple Sclerosis research group at the Ruhr University in Bochum . Sindern held an extraordinary professorship at the Ruhr-Universität Bochum from 2004 to 2006 and has held an extraordinary professorship at the Hannover Medical School since 2006. Since November 2005 he has been the chief physician of the neurological clinic in Diakovere Friederikenstift. From 2010 to 2013 he was medical director at the Diakoniekrankenhaus Friederikenstift, today Diakovere Friederikenstift.

Clinical-scientific contribution

After completing his dissertation, Sindern worked as an assistant at the Hanover Medical School with clinical issues related to multiple sclerosis (MS) and Guillain-Barré syndrome (GBS). At the Ruhr University in Bochum , he focused on the characterization of cell activation mechanisms in blood and liquor in inflammatory diseases of the nervous system . The cytokine expression and release and the characterization of lymphocyte subpopulations in blood and cerebrospinal fluid were examined in particular in MS and GBS and correlated with clinical data. The role of chemokines and their receptors in the pathogenesis of MS was later investigated. Together with Focke Ziemsen and Matthias Vorgerd , investigations into adult polyglucosan body disease were carried out with evidence of new mutations and enzyme defects in various tissues. In addition to clinical and laboratory work, Sindern also deals with expert questions in the case of inflammatory diseases of the nervous system.

Publications

Books

  • Hela-Felicitas Petereit, Eckhart Sindern, Manfred Wick (authors, eds.): Liquordiagnostik: Guidelines for Liquordiagnostik and method catalog of the German Society for Liquordiagnostik and Clinical Neurochemistry. 1st edition. Springer, Berlin / Heidelberg 2007, ISBN 978-3-540-39017-6 .
  • Volker Limmroth, Eckhart Sindern, Karin Baum: Multiple Sclerosis: Pocket Atlas special. 1st edition. Thieme, 2004, ISBN 3-13-133281-6 . (1st Portuguese edition 2006.)

Scientific Article

Web links

Individual evidence

  1. ↑ E. Sindern Vita ( Memento of the original from February 24, 2017 in the Internet Archive ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.diakovere.de
  2. ^ E. Sindern, J. Haas, E. Stark, U. Wurster: Early onset MS under the age of 16: clinical and paraclinical features. In: Acta Neurol Scand. 86, 1992, pp. 280-284. doi: 10.1111 / j.1600-0404.1992.tb05086.x
  3. ↑ E. Sindern, JP Malin: The acute Guillain-Barré syndrome. In: Deutsches Ärzteblatt. 93rd volume, issue 28/29, 1996, pp. 1895–1898.
  4. ↑ E. Sindern, K. Schweppe, LM Ossege, JP Malin: Potential role of transforming growth factor-ß1 in terminating the immune response in patients with Guillain-Barré syndrome. In: J Neurol. 243, 1996, pp. 264-268.
  5. ↑ KF Haegele, CA Stueckle, JP Malin, E. Sindern: Increase of CD8 + T-effector memory cells in peripheral blood of patients with relapsing-remitting multiple sclerosis compared to healthy controls. In: J Neuroimmunol. 183, 2007, pp. 168-174. doi: 10.1016 / j.jneuroim 2006.09.008
  6. ^ E. Sindern, T. Patzold, LM Ossege, A. Gisevius, JP Malin: Expression of chemokine receptor CXCR3 on cerebrospinal fluid T-cells is related to active MRI lesion appearance in patients with relapsing-remitting multiple sclerosis. In: J Neuroimmunol. 131, 2002, pp. 186-190.
  7. ↑ E. Sindern: Role of chemokines and their receptors in the pathogenesis of multiple sclerosis. In: Front Biosci. 9, 2004, pp. 457-463.
  8. ↑ F. Ziemsen, E. Sindern, JM Schröder, YS Shin, J. Zange, MW Kilimann, JP Malin, M. Vorgerd: Novel missense mutations in the glycogen branching enzyme gene in adult polyglucosan body disease (APBD). In: Ann Neurol. 47, 2000, pp. 536-540.
  9. ↑ E. Sindern, F. Ziemsen, T. Ziemsen, T. Podskarbi, Y. Shin, F. Brasch, KM Müller, JM Schröder, JP Malin, M. Vorgerd: Adult polyglucosan body disease: A postmortem correlation study. In: Neurology. 61, 2003, pp. 263-265.
  10. ↑ E. Sindern: Inflammatory diseases of the nervous system (Chapter 6.2). In: E. Fritze, B. May (Ed.): The medical assessment. 8th edition. Steinkopff-Verlag, Darmstadt 2012.
personal data
SURNAME Sindern, Eckhart
BRIEF DESCRIPTION German neurologist
DATE OF BIRTH 1960
PLACE OF BIRTH Kiel