Erik Adolf von Willebrand

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Erik Adolf von Willebrand (born February 1, 1870 in Vasa , † December 12, 1949 in Pernå ) was a Finnish internist and hematologist . He is best known as the namesake of the Willebrand-Jürgens syndrome , a hemophilia .

biography

Erik von Willebrand as a child was Finland-Swedish parents in what was then the Russian Empire belonging Grand Duchy of Finland was born. He studied medicine at the University of Helsinki , where he qualified as a doctor in 1896 and in 1899 with the work on the knowledge of blood changes after phlebotomy. An experimental study. received his doctorate . Blood diseases formed his scientific focus throughout his further career. From 1901 to 1903 he gave anatomy lectures at the University of Helsinki, habilitated there in 1903 for physical therapy and 1907 for internal medicine and from 1908 he taught internal medicine there. He taught at the university until his retirement in 1935. From 1908 to 1935 he was director of the department of internal medicine at the Diakonie Hospital in Helsinki.

In 1926 von Willebrand published the work Hereditär pseudohemofili , in which he described Von Willebrand syndrome , later named after him , a hereditary blood clotting disorder which he had observed in a family from the Åland Islands and which, in contrast to hemophilia , the classic hemophilia also affected women. He therefore called it hereditary pseudohemophilia . Von Willebrand recognized that there were mild and severe cases of the disease and suspected a dominant inheritance . After he was appointed honorary professor in 1930, he and Rudolf Jürgens re- examined the family from the Åland Islands again in the 1930s, and the studies published by both of them led to the disease resulting in Von Willebrand-Jürgens thrombopathy The term Willebrand-Jürgens syndrome is still used today mainly in German-speaking countries, while the term Von Willebrand syndrome or disease is generally used internationally . In the 1950s, a factor that shortens bleeding time was described as causally involved in the disease. This factor was later identified as a protein and was named Von Willebrand factor .

von Willebrand published a total of 40 scientific papers between 1899 and 1945, including 29 in Swedish and 11 in German.

literature

Web links

Individual evidence

  1. ↑ Hjelt, Otto Edvard August (ed.): Det Finska universitetets disputations- och program-literature under åren 1828-1908 systematiskt ordnad. Disserertationes academicæ et programmata Universitatis litterarum Fennorum Helsingforsiæ annis 1828-1908 edita . 1909, p. 85 (Swedish, online at archive.org ).
  2. ↑ Erik Berntorp: Erik von Willebrand . In: Thrombosis Research . tape 120 , 2007, pp. S3-S4 , doi : 10.1016 / j.thromres.2007.03.010 , PMID 17512040 (English).
  3. ↑ Hereditary pseudohemofili. In: Finska Läkaresällskapets Handlingar. Volume 68, 1926, pp. 87-112.
  4. ↑ The work was published in 1999 in English translation: EA Von Willebrand: Hereditary pseudohaemophilia. In: Haemophilia. 5, 1999, pp. 223-231, doi : 10.1046 / j.1365-2516.1999.00302.x .
  5. ↑ Birger Blombäck: A Journey with Bleeding Time Factor. In: Giorgio Semenza : Stories of Success: Personal Recollections. 10 Amsterdam; Boston; Paris [etc.]: Elsevier, 2007., ISBN 9780444522467 ( online ) pp. 211-212
  6. ↑ Erik Berntorp, Margareta Blombäck: Historical perspective on von Willebrand disease. In: Augusto B. Federici, Christine A. Lee: Von Willebrand Disease. Basic and Clinical Aspects Wiley-Blackwell, 2011, ISBN 9781405195126 ( online )
  7. ↑ Birger Blombäck: A Journey with Bleeding Time Factor. P. 213 ff.
  8. ^ R. Lassila, O. Lindberg: Erik von Willebrand . In: Haemophilia . 2013, p. 643–647 , doi : 10.1111 / hae.12243 (English, pdf ).
personal data
SURNAME Willebrand, Erik Adolf von
BRIEF DESCRIPTION Finnish hematologist
DATE OF BIRTH February 1, 1870
PLACE OF BIRTH Vaasa , Finland
DATE OF DEATH December 12, 1949
Place of death Pernå , Finland