Erik van Nijmegen

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Erik van Nijmegen (2011)

Erik Jan van Nimwegen (born November 5, 1970 in Amsterdam ) is a Dutch bioinformatician and professor at the Biozentrum of the University of Basel , Switzerland .

Life

Erik van Nimwegen studied theoretical physics at the University of Amsterdam . He received his PhD from the Santa Fe Institute (SFI) in Santa Fe, New Mexico, and received his PhD from the Faculty of Biology at Utrecht University in 1999 . Erik van Nimwegen then did research as a postdoc for another year at the Santa Fe Institute and three years at the Center of Studies in Physics and Biology at Rockefeller University , New York. In 2003 Erik van Nimwegen was appointed professor of bioinformatics at the Biozentrum of the University of Basel. Since 2004 he has also been a group leader at the Swiss Institute of Bioinformatics (SIB), Basel.

Act

Erik van Nimwegen researches the evolution of the genome and the function and evolution of regulatory networks that cells use to control gene expression . He develops mathematical models to analyze the development and functioning of the regulatory networks and designs computer methods with the help of which such networks can be reconstructed on the basis of extensive biological data sets.

Van Nijmegen's research deals with a general evolution model for the robustness of the genome against mutations and the identification of universal laws of scale for genome evolution. Further research focuses are the development of general Bayesian methods for predicting transcription factor and miRNA binding sites as well as the development of models for deriving regulatory networks from genome-wide expression data and data on the state of chromatin .

Awards

Since 2010 member of the editorial team of the PLoS Computational Biology Journal.

Publications (selection)

Complete list of publications

  • E. van Nimwegen, JP Crutchfield, M. Huynen: Neutral evolution of mutational robustness. In: Proceedings of the National Academy of Sciences . Volume 96, No. 17, August 17, 1999, pp. 9716-9720, PMID 10449760
  • E. van Nimwegen: Scaling laws in the functional content of genomes. In: Trends Genet. Volume 19, No. 9, September 2003, pp. 479-484, PMID 12957540
  • R. Siddharthan, ED Siggia, E. van Nimwegen: PhyloGibbs: a Gibbs sampling motif finder that incorporates phylogeny. In: PLoS Comput Biol. Volume 1, No. 7, December 2005, e67, Epub 2005 Dec 9. PMID 16477324
  • L. Burger, E. van Nimwegen :. Accurate prediction of protein-protein interactions from sequence alignments using a Bayesian method. In: Mol Syst Biol. Volume 4, 2008, p. 165, doi: 10.1038 / msb4100203 , Epub 2008 Feb 12, PMID 18277381
  • FANTOM Consortium: H. Suzuki, A. R Forrest, E. van Nimwegen et al: The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. In: Nat Genet. Volume 41, No. 5, May 2009, pp. 553-562, doi: 10.1038 / ng.375 , Epub 2009 Apr 19, PMID 19377474

Web links

Individual evidence

  1. ↑ Curriculum Vitae biozentrum.unibas.ch, accessed on May 20, 2014
  2. ^ SIB Group Erik van Nimwegen isb-sib.ch, accessed on May 20, 2014
  3. ↑ ISMARA: Automated modeling of genomic signals as a democracy of regulatory motifs genome.cshlp.org, accessed on May 20, 2014
  4. ↑ New biophysical model predicts regulation by microRNAs  ( page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice. unibas.ch, accessed on May 20, 2014@1@ 2Template: Dead Link / www.unibas.ch  
  5. ↑ PLOS Computational Biology Editorial Board ploscompbiol.org, accessed May 20, 2014
  6. ↑ Complete list of publications Biozentrum.unibas.ch, accessed on May 20, 2014
personal data
SURNAME Nijmegen, Erik van
ALTERNATIVE NAMES Nijmegen, Erik Jan van (full name)
BRIEF DESCRIPTION Dutch bioinformatician and professor at the Biozentrum of the University of Basel, Switzerland
DATE OF BIRTH 5th November 1970
PLACE OF BIRTH Amsterdam