|Properties of human protein|
|Mass / length primary structure||91,733 daltons / 854 amino acids (isoform 1)
31,636 daltons / 288 amino acids (isoform 2)
|Gene names||DFNB36, LP2654|
Espin is a protein that organizes actin filaments into bundles. It plays a major role in the organization, dynamics and regulation of microvillus- like specializations of the cell membrane that mediate sensory signal transduction in various mechano- and chemosensory cells. Espin is encoded by the ESPN gene . Mutations in this gene can autosomal - recessive neurosensory deafness and autosomal dominant cause sensorineural deafness without impairment of balance
Depending on its function, Espin is found subcellularly on the cytoskeleton , stereocilia and microvillus . It binds about his WH2- domain of F-actin and formed it to calcium ion-resistant bundles and interacts with its N -terminus with the SH3 domain of BAIAP2 and also with PFN2 . It also has 9 ANK motifs.