Espin (protein)
Espin | ||
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other names |
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Properties of human protein | ||
Mass / length primary structure | 91,733 daltons / 854 amino acids (isoform 1)
31,636 daltons / 288 amino acids (isoform 2) |
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Isoforms | 2 | |
Identifier | ||
Gene names | ESPN DFNB36, LP2654 | |
External IDs | ||
Orthologue | ||
human | House mouse | |
Entrez | 83715 | 56226 |
Ensemble | ENSG00000187017 | ENSMUSG00000028943 |
UniProt | B1AK53 | Q9ET47 |
Refseq (mRNA) | NM_031475 | NM_019585 |
Refseq (protein) | NP_113663 | NP_062531 |
Gene locus | Chr 1: 6.42 - 6.46 Mb | Chr 4: 152.12 - 152.15 Mb |
PubMed search | 83715 |
56226
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Espin is a protein that organizes actin filaments into bundles. It plays a major role in the organization, dynamics and regulation of microvillus- like specializations of the cell membrane that mediate sensory signal transduction in various mechano- and chemosensory cells. Espin is encoded by the ESPN gene . Mutations in this gene can autosomal - recessive neurosensory deafness and autosomal dominant cause sensorineural deafness without impairment of balance
Depending on its function, Espin is found subcellularly on the cytoskeleton , stereocilia and microvillus . It binds about his WH2- domain of F-actin and formed it to calcium ion-resistant bundles and interacts with its N -terminus with the SH3 domain of BAIAP2 and also with PFN2 . It also has 9 ANK motifs.