Espin (protein)

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other names
  • Autosamal recessive deafness protein type 36
  • Ectoplasmic specialization protein
Properties of human protein
Mass / length primary structure 91,733 daltons / 854 amino acids (isoform 1)

31,636 daltons / 288 amino acids (isoform 2)

Isoforms 2
Gene names ESPN DFNB36, LP2654
External IDs
human House mouse
Entrez 83715 56226
Ensemble ENSG00000187017 ENSMUSG00000028943
UniProt B1AK53 Q9ET47
Refseq (mRNA) NM_031475 NM_019585
Refseq (protein) NP_113663 NP_062531
Gene locus Chr 1: 6.42 - 6.46 Mb Chr 4: 152.12 - 152.15 Mb
PubMed search 83715 56226

Espin is a protein that organizes actin filaments into bundles. It plays a major role in the organization, dynamics and regulation of microvillus- like specializations of the cell membrane that mediate sensory signal transduction in various mechano- and chemosensory cells. Espin is encoded by the ESPN gene . Mutations in this gene can autosomal - recessive neurosensory deafness and autosomal dominant cause sensorineural deafness without impairment of balance

Depending on its function, Espin is found subcellularly on the cytoskeleton , stereocilia and microvillus . It binds about his WH2- domain of F-actin and formed it to calcium ion-resistant bundles and interacts with its N -terminus with the SH3 domain of BAIAP2 and also with PFN2 . It also has 9 ANK motifs.

Individual evidence

  1. a b UniProt B1AK53
  2. ESPN espin (human)