Ankyrin

The structure of part of the membrane-binding structure of ankyrin

Ankyrins are repeat proteins that, like antibodies, belong to the binding proteins. Ankyrins are cytoskeletal proteins that interact with integral membrane proteins via dynamic, non- covalent bonds and help determine their distribution within the cell membrane .

In erythrocytes , spectrin binds to the cell membrane via ankyrin .

The hereditary spherocytosis half of the cases is based roughly on a deletion in the ankyrin gene. Plasmodium falciparum binds to ankyrin. ANK3 (Ankyrin G) may be involved in the development of bipolar disorder .

literature

• Peter Michaely, Diana R. Tomchick, Mischa Machius, Richard GW Anderson: Crystal structure of a 12 ANK repeat stack from human ankyrinR. In: The EMBO Journal . 21, No. 23, 2002, pp. 6387-6396, doi : 10.1093 / emboj / cdf651 , PMID 12456646 , PMC 136955 (free full text).
• Vann Bennett, Anthony J. Baines: Spectrin and Ankyrin-Based Pathways: Metazoan Inventions for Integrating Cells Into Tissues. In: Physiological Reviews . 81, No. 3, 2001, pp. 1353-1392, PMID 11427698 .
• Patrick A Singleton, Lilly Y. W Bourguignon: CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca ²⁺ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation. In: Experimental Cell Research . 295, No. 1, 2004, pp. 102-118, doi : 10.1016 / j.yexcr.2003.12.025 , PMID 15051494 .

Individual evidence

1. ↑ V. Bennett, PJ Stenbuck: Identification and partial purification of ankyrin, the high affinity membrane attachment site for human erythrocyte spectrin. In: Journal of Biological Chemistry . 254, No. 7, 1979, pp. 2533-2541, PMID 372182 .
2. ↑ Samuel E. Lux et al .: Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8. In: Nature . 345, No. 6277, 1990, pp. 736-739., Doi : 10.1038 / 345736a0 , PMID 2141669 .
3. ↑ V. Bennett, PJ Stenbuck: Identification and partial purification of ankyrin, the high affinity membrane attachment site for human erythrocyte spectrin. In: Journal of Biological Chemistry. 254, No. 7, 1979, pp. 2533-2541, doi : 10.1016 / j.bbamem.2013.09.014 , PMID 372182 .
4. ↑ Manuel AR Ferreira et al: Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. In: Nature Genetics . 40, No. 9, 2008, pp. 1056-1058, doi : 10.1038 / ng.209 , PMID 18711365 , PMC 2703780 (free full text).