Experimental murine autoimmune hepatitis

Experimental murine autoimmune hepatitis (emAIH) is a mouse model that exhibits the key characteristics of autoimmune hepatitis (AIH) in humans.

features

The most important similarities between the AIH in humans and the emAIH are:

a chronic course of the disease and the development of fibrosis
the dependence on genetic predisposition , ie the animals are predisposed to autoimmunity
the need for a strong external stimulus ( environmental factor ) such as B. a viral infection , so that the disease breaks out
the strong infiltration of the portal fields of the liver by lymphocytes
an autoimmune response by CD4 ⁺ T cells against liver self-antigens
effective therapeutic treatment using corticosteroids such as prednisolone or budesonide

root cause

The emAIH is not a spontaneous disease in animals, therefore the emAIH is induced by a single administration of adenoviruses in NOD mice . The adenoviruses serve both as an environmental factor that triggers an immune reaction and as a viral vector to express the human liver protein formiminotransferase-cyclodeaminase (FTCD) in mouse liver. The foreign antigen in the liver and the infection start an autoimmune reaction that takes a chronic course, becomes stronger and kills the liver cells ( hepatocytes ).

Individual evidence

↑ Matthias Hardtke-Wolenski, Katja Fischer, Fatih Noyan, Jerome Schlue, Christine S. Falk, Maike Stahlhut, Norman Woller, Florian Kuehnel, Richard Taubert, Michael P. Manns, Elmar Jaeckel: Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis driven by CD4 ⁺ T cells . In: Hepatology . tape 58 , no. 2 , August 2013, p. 718 , doi : 10.1002 / hep.26380 .
↑ MP Manns, M. Woynarowski, W. Kreisel, Y. Lurie, C. Rust, E. Zuckerman, MJ Bahr, R. Guenther, RW Hultcrantz, U. Spengler, AW Lohse, F. Szalay, M. Färkkilä, M Pröls, CP Strasbourg, European AIH-BUC-Study Group: Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis. In: Gastroenterology . 2010; 139, pp. 1198-1206.

[1] Matthias Hardtke-Wolenski, Katja Fischer, Fatih Noyan, Jerome Schlue, Christine S. Falk, Maike Stahlhut, Norman Woller, Florian Kuehnel, Richard Taubert, Michael P. Manns, Elmar Jaeckel: Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis driven by CD4 ⁺ T cells . In: Hepatology . tape 58 , no. 2 , August 2013, p. 718 , doi : 10.1002 / hep.26380 .

[2] MP Manns, M. Woynarowski, W. Kreisel, Y. Lurie, C. Rust, E. Zuckerman, MJ Bahr, R. Guenther, RW Hultcrantz, U. Spengler, AW Lohse, F. Szalay, M. Färkkilä, M Pröls, CP Strasbourg, European AIH-BUC-Study Group: Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis. In: Gastroenterology . 2010; 139, pp. 1198-1206.