Formiminotransferase-cyclodesaminase

Formiminotransferase-cyclodesaminase
other names	LCHC1
	Existing structural data : 1TT9 , 1QD1
Properties of human protein
Mass / length primary structure	58,927 Da / 541 AS
Cofactor	Pyridoxal phosphate
Identifier
Gene name	FTCD
External IDs	GeneCards : FTCD ; OMIM : 606806 ; UniProt : O95954 ; MGI : 1339962 ;
Enzyme classification
EC, category	4.3.1.4 , lyase

Formiminotransferase cyclodesaminase (FTCD) is a bifunctional enzyme that catalyzes the conversion of formiminoglutamate and tetrahydrofolate to formiminotetrahydrofolate and glutamate .

Importance as a diagnostic marker

An alternative name for the FTCD is Liver Cytosolic Antigen (LC-1). The presence of antibodies against LC-1 (anti-LC1) is a marker for type 2 autoimmune hepatitis . However, antibodies to FTCD can also be found in patients with chronic hepatitis C virus infection.

Individual evidence

↑ UniProt O95954
↑ P. Lapierre, O. Hajoui, J.-C. Homberg, F. Alvarez: Formiminotransferase cyclodeaminase is an organ-specific autoantigen recognized by sera of patients with autoimmune hepatitis. In: Gastroenterology. 116, 1999, pp. 643-649. doi: 10.1016 / S0016-5085 (99) 70186-1 .
^ R. Liberal, CR Grant, MS Longhi, G. Mieli-Vergani, D. Vergani: Diagnostic criteria of autoimmune hepatitis. In: Autoimmun Rev. 13 (4-5), 2014, pp. 435-440. doi: 10.1016 / j.autrev.2013.11.009 .

[1] UniProt O95954

[2] P. Lapierre, O. Hajoui, J.-C. Homberg, F. Alvarez: Formiminotransferase cyclodeaminase is an organ-specific autoantigen recognized by sera of patients with autoimmune hepatitis. In: Gastroenterology. 116, 1999, pp. 643-649. doi: 10.1016 / S0016-5085 (99) 70186-1 .

[3] R. Liberal, CR Grant, MS Longhi, G. Mieli-Vergani, D. Vergani: Diagnostic criteria of autoimmune hepatitis. In: Autoimmun Rev. 13 (4-5), 2014, pp. 435-440. doi: 10.1016 / j.autrev.2013.11.009 .