Feedback inhibition

from Wikipedia, the free encyclopedia

The term feedback inhibition , also known as “feedback inhibition”, is used in enzymology and endocrinology . In the metabolism of living beings there are many control loops made possible by negative feedback .

Enzymology

By feedback inhibition occurs when an image formed by an enzyme product, or one of the derivatives retroactively inhibitory effect on the activity of this enzyme or enzymes that chain. It inhibits its own production and prevents overproduction. This so-called end product inhibition is a form of negative feedback.

endocrinology

Here feedback inhibition describes a similar situation when a releasing hormone is released from a primary source (e.g. hypothalamus ) , and this in the secondary source (e.g. adenohypophysis ) promotes the release of a glandotropic hormone, which in turn in the tertiary source ( Hormone gland ) now causes the release of the actual hormone (e.g. cortisol ). The inhibition of a further release can now take place via the hormone itself at the primary or secondary source (long route) or partially even from the glandotropic hormone only at the primary source (short route).

Behavioral biology

There is also feedback with inhibition of feedback in the regulation of behavior .

Individual evidence

  1. ^ Alberts , Bray, Johnson, Lewis: Textbook of Molecular Cell Biology, 2nd, corrected edition Wiley-VCH, Weinheim 2001, ISBN 3-527-30493-2 .