Frank Buchholz (biologist)

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Frank Buchholz (* 1966 in Bremen ) is a German molecular biologist.

Life

Buchholz began studying biology at the University of Göttingen in 1987 , where he received his diploma from Michael G. Rosenfeld and Hans J. Fritz in 1993 ( identification, cloning and characterization of the tissue-specifically expressed gene zip I in rats ). In 1993 he was at the University of California, San Diego , and from 1994 at the European Molecular Biology Laboratory (EMBL) in Heidelberg, where he received his doctorate in 1997 under A. Francis Stewart ( Investigation and development of site specific recombinases for advanced genomic engineering ) . As a post-doctoral student he was in the gene expression program at EMBL, where he developed recombinases using the directed evolution method, and from 1998 to 2001 at the University of California, San Francisco , with J. Michael Bishop . There he worked on genetically engineered leukemia in the mouse model. Since 2002 he has been group leader at the Max Planck Institute for Molecular Cell Biology and Genetics (MPI-CBG) in Dresden in the research field of programming and reprogramming of mammalian cells in vivo and in vitro with the aim of decoding the functions of the various genes in mammalian cells (functional Genomics). Since 2010 he has been Professor of Medical Systems Biology at the University Medical Center Dresden . In 2016 he was elected to the European Molecular Biology Organization .

With Joachim Hauber and Ilona Hauber from the Heinrich Pette Institute for Experimental Virology and Immunology in Hamburg and Indrani Sarkar from the MPI-CBG, he achieved a widely recognized breakthrough in AIDS research in 2007 - they succeeded in the targeted removal of virus DNA from host cells in in vitro with the help of recombinases produced for this purpose using methods of targeted evolution.

With his group, he developed a method for producing siRNA in large quantities at low cost using endoribonuclease . These are small, "tailor-made" RNA molecules that can be used to switch off gene expression in cells. They called the process esiRNA and founded the company Eupheria Biotech in Dresden in 2010 for commercial exploitation. The method is used by his group for the screening of gene expression in cells.

Web links

Individual evidence

  1. ^ Hauber, Hauber, Sarkar, Buchholz: HIV-1 Proviral DNA Excision Using an Evolved Recombinase , Science, Volume 316, 2007, pp. 1912-1915, abstract
personal data
SURNAME Buchholz, Frank
BRIEF DESCRIPTION German molecular biologist
DATE OF BIRTH 1966
PLACE OF BIRTH Bremen