Frauke Melchior

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Frauke Melchior (born November 2, 1962 in Heidelberg ) is a German chemist and university professor at the Ruprecht-Karls-Universität Heidelberg . Melchior discovered the SUMO protein family (from small ubiquitin-like modifier ) and its function as a post-translational modification of proteins. Your scientific working group deals with the characterization of the SUMO protein. Melchior was Dean of the Faculty of Biosciences at Heidelberg University from 2016 to 2018 .

Career

Frauke Melchior studied chemistry at the University of Marburg . There she completed her doctorate in 1990 in Helmut Kindl's laboratory . She spent her first postdoc at the Max Planck Institute for Biophysical Chemistry , Göttingen with Volker Gerke before moving to the laboratory of Larry Gerace for her second postdoc position in 1992 at the Scripps Research Center , La Jolla. Here Melchior discovered during her work on RanGAP, an enzyme responsible for nuclear transport , that the recruitment of RanGAP to the nuclear pore is regulated by coupling to another small protein. The newly discovered protein was named SUMO protein (Small Ubiquitin-like Modifier) ​​and accordingly the process of modification is called sumoylation . In 1998 Melchor returned to Germany as a group leader at the Max Planck Institute for Biochemistry , Martinsried. In 2004 she became a full professor at the University of Göttingen . Melchior has been a professor at the Center for Molecular Biology Heidelberg (ZMBH) since 2008 . From 2016 to 2018 Melchior was Dean of the Faculty of Biosciences at Heidelberg University.

Research focus

Frauke Melchior researches the post-translational modification of proteins by sumoylation. Her laboratory is particularly concerned with the characterization of the process by identifying the enzymes, target proteins and binding sites involved. Melchior is also investigating the role of sumoylation in nuclear transport and the regulation of sumoylation by reactive oxygen species.

Awards

In 1999 Melchior won the BioFuture competition organized by the Federal Minister for Education and Research. In 2005 she won the Binder Innovation Award. Melchior received the EMBO Women in Science Award in 2018 for her work on the regulation of sumoylation through oxidative stress and her role as a mentor to young scientists.

Since 2008 she has been a member of the European Molecular Biology Organization (EMBO), since 2014 a member of the Leopoldina - National Academy of Sciences . She also acts as a DFG Senate member.

Publications (selection)

literature

  • Jörg Hacker (Ed.): Leopoldina . Yearbook 2014. Series 3, year 60. German Academy of Sciences Leopoldina eV - National Academy of Sciences, Halle (Saale) 2015, ISBN 978-3-8047-3450-0 , p. 107-108 ( online [PDF; 20.1 MB ]).

Individual evidence

  1. ↑ a b c d e Frauke Melchior: How SUMO wrestles other proteins. Interview by Caitlin Sedwick. . In: The Journal of cell biology . 187, No. 5, September, pp. 586-7. doi : 10.1083 / jcb.1875pi . PMID 19951911 .
  2. ↑ SFB TRR186. Retrieved March 7, 2020 .
  3. ↑ A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. . In: Cell . 88, No. 1, September, pp. 97-107. doi : 10.1016 / s0092-8674 (00) 81862-0 . PMID 9019411 .
  4. ↑ a b Melchior Lab .
  5. ↑ Deans, Vice Deans and Deans of Studies University of Heidelberg 2017 . April 1, 2017. Retrieved March 7, 2020.
  6. ↑ The nucleoporin RanBP2 has SUMO1 E3 ligase activity. . In: Cell . 108, No. 1, September, pp. 109-20. doi : 10.1016 / s0092-8674 (01) 00633-x . PMID 11792325 .
  7. ↑ Control of SUMO and Ubiquitin by ROS: Signaling and disease implications . In: Molecular Aspects of Medicine . 63, September, pp. 3-17. doi : 10.1016 / j.mam.2018.07.002 .
  8. ^ Binder Innovation Prize .
  9. ↑ FEBS | Frauke Melchior receives the 2018 FEBS | EMBO Women in Science Award | News . Retrieved March 7, 2020.
  10. ↑ EMBO members . Retrieved March 7, 2020.
  11. ^ Leopoldina membership directory . Retrieved March 7, 2020.
  12. ^ Six New Members in DFG Senate . Retrieved March 7, 2020.
personal data
SURNAME Melchior, Frauke
BRIEF DESCRIPTION German chemist and university professor, discoverer of the SUMO protein
DATE OF BIRTH November 2nd, 1962
PLACE OF BIRTH Heidelberg