Fritz Eckstein

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Fritz Eckstein (born September 7, 1932 in Darmstadt ) is a German chemist .

life and work

In 1960 Eckstein received his doctorate from Burckhardt Helferich in Bonn. rer. nat. In 1960 and 1961 he was a postdoctoral fellow with Erich Baer in Toronto and in 1962 and 1963 with Robert B. Woodward at Harvard University . In 1964 he became a research assistant at the Max Planck Institute for Experimental Medicine in Göttingen. In 1968 he completed his habilitation in Braunschweig. Since 1975 he has been an adjunct professor at the Institute for Organic Chemistry at the University of Göttingen .

Eckstein's specialty is bio-organic chemistry , especially nucleic acid chemistry. He studied DNA and RNA polymerase and modified oligonucleotides . His greatest merit was the introduction of the phosphorothioate group, which allowed stereochemical studies and proved helpful in DNA sequencing. The phosphorothioate group is also used for gene silencing using antisense RNA . Eckstein also works with ribozymes .

Publications

Eckstein published more than 450 papers, including:

  • To the knowledge of a new glycoside synthesis from 1-mesitoylaldoses . Dissertation, Bonn 1960
  • Nucleoside Phosphorothioates . Habilitation thesis, Braunschweig, 1968

Awards

  • 1972: Carl Duisberg Memorial Prize ( Society of German Chemists )
  • 1992: Alexander von Humboldt Gay Lussac Award
  • 2000: Richard Kuhn Medal (Society of German Chemists)

literature

  • Kurt Begitt (editor), Society of German Chemists (editor): Chemistry and Biochemistry in Germany . 2nd edition, VCH, Weinheim [u. a.] 1995, pp. 301f., ISBN 3-527-29258-6

Web links

Individual evidence

  1. ↑ Life data, publications and academic family tree of Fritz Eckstein at academictree.org, accessed on January 31, 2018.
personal data
SURNAME Eckstein, Fritz
BRIEF DESCRIPTION German chemist
DATE OF BIRTH September 7, 1932
PLACE OF BIRTH Darmstadt