GRIA 1

Glutamate receptor, ionotropic, AMPA 1
Properties of human protein
Mass / length primary structure	888 amino acids
Secondary to quaternary structure	multipass membrane protein, homo- / heterotetramer
Isoforms	Flip, flop
Identifier
Gene names	GRIA1 ; GLUR1; GLURA
External IDs	OMIM : 138248 ; UniProt : P42261 ; MGI : 95808 ;
Transporter classification
TCDB	1.A.10
designation	Glutamate-gated ion channel
Occurrence
Homology family	CG3822 PA
Parent taxon	Bilateria
	Orthologue

The ionotropic glutamate receptor, AMPA 1 , also known as GRIA1 , is a human protein .

Glutamate receptors are the predominant form of excitatory neurotransmitter receptors in the mammalian brain. They are activated by a variety of neurophysiological processes. They are heteromeric protein complexes consisting of different subunits, each of which has a transmembrane domain and which together form a ligand-gated ion channel. The classification of the glutamate receptors is based on their activation by various agonists. The GRIA1 belongs to the AMPA receptor family . For each of the four GRIAs, so-called flip-flop isoforms are known, which are generated by alternative splicing . The receptor subunits of the various isoforms differ in their signal transmission properties. By in situ hybridization it was possible to show that GRIA1 mRNA is predominantly expressed in the granule cell band and in the pyramidal cells of the hippocampus .

Recommended literature

Sun W, Ferrer-Montiel AV, Schinder AF, et al. : `` Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. '' In: Proc. Natl. Acad. Sci. USA vol. 89.4 pg. 1443-7 (1992) PMID 1311100
McNamara JO, Eubanks JH, McPherson JD, et al. : `` Chromosomal localization of human glutamate receptor genes. '' In: J. Neurosci. vol. 12.7 pg. 2555-62 (1992) PMID 1319477
Potier MC, Spillantini MG, Carter NP: `` The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. '' in: DNA Seq. vol. 2.4 pg. 211-8 (1992) PMID 1320959
Puckett C, Gomez CM, Korenberg JR, et al. : `` Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. '' In: Proc. Natl. Acad. Sci. USA vol. 88.17 pg. 7557-61 (1991) PMID 1652753
Yakel JL, Vissavajjhala P, Derkach VA, et al. : `` Identification of a Ca2 + / calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors. '' In: Proc. Natl. Acad. Sci. USA vol. 92.5 pg. 1376-80 (1995) PMID 7877986
Eastwood SL, Burnet PW, Beckwith J, et al. : `` AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus. '' In: Neuroreport vol. 5.11 pg. 1325-8 (1994) PMID 7919190
Roche KW, Raymond LA, Blackstone C, Huganir RL: `` Transmembrane topology of the glutamate receptor subunit GluR6. '' In: J. Biol. Chem. Vol. 269.16 pg. 11679-82 (1994) PMID 8163463
McLaughlin DP, Cheetham ME, Kerwin RW: `` Expression of alternatively-spliced glutamate receptors in human hippocampus. '' In: Eur. J. Pharmacol. vol. 244.1 pg. 89-92 (1993) PMID 8420792
Roche KW, O'Brien RJ, Mammen AL, et al. : `` Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. '' In: Neuron vol. 16.6 pg. 1179-88 (1996) PMID 8663994
Brakeman PR, Lanahan AA, O'Brien R, et al. : `` Homer: a protein that selectively binds metabotropic glutamate receptors. '' In: Nature vol. 386.6622 pg. 284-8 (1997) PMID 9069287
Barria A, Derkach V, Soderling T: '' Identification of the Ca2 + / calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor. ' 'in: J. Biol. Chem. vol. 272.52 pg. 32727-30 (1998) PMID 9407043
Ripellino JA, Neve RL, Howe JR: `` Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum. '' In: Neuroscience vol. 82.2 pg. 485-97 (1998) PMID 9466455
Leonard AS, Davare MA, Horne MC, et al. : `` SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. '' In: J. Biol. Chem. Vol. 273.31 pg. 19518-24 (1998) PMID 9677374
Xiao B, Tu JC, Petralia RS, et al. : `` Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. '' In: Neuron vol. 21.4 pg. 707-16 (1998) PMID 9808458
Montague AA, Greer CA: `` Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb. '' In: J. Comp. Neurol. vol. 405.2 pg. 233-46 (1999) PMID 10023812
Leuschner WD, Hoch W: `` Subtype-specific assembly of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is mediated by their n-terminal domains. '' In: J. Biol. Chem . vol. 274.24 pg. 16907-16 (1999) PMID 10358037
Shi SH, Hayashi Y, Petralia RS, et al. : `` Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. '' In: Science vol. 284.5421 pg. 1811-6 (1999) PMID 10364548
Rubio ME, Wenthold RJ: `` Calnexin and the immunoglobulin binding protein (BiP) coimmunoprecipitate with AMPA receptors. '' In: J. Neurochem. vol. 73.3 pg. 942-8 (1999) PMID 10461883
Mahlknecht U , Bucala R, Hoelzer D, Verdin E: `` High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region. '' In: Cytogenet. Cell Genet. vol. 86.3-4 pg. 237-9 (2000) PMID 10575214
Stinehelfer S, Vruwink M, Burette A: `` Immunolocalization of mGluR1alpha in specific populations of local circuit neurons in the cerebral cortex. '' In: Brain Res. Vol. 861.1 pg. 37-44 (2000) PMID 10751563

Individual evidence

↑ ^a ^b Entrez Gene: GRIA1 glutamate receptor, ionotropic, AMPA 1 . Retrieved December 31, 2010.

[entrez-1] Entrez Gene: GRIA1 glutamate receptor, ionotropic, AMPA 1 . Retrieved December 31, 2010.

GRIA 1

See also

Recommended literature

Individual evidence