Prolactin Induced Protein

from Wikipedia, the free encyclopedia
Prolactin Induced Protein
Prolactin Induced Protein

Existing structure data : 3ES6

Properties of human protein
Mass / length primary structure 16.6 kilodaltons / 146 amino acids
Secondary to quaternary structure Monomer
Identifier
Gene names PIP GCDFP-15; GCDFP15; GPIP4
External IDs
Occurrence
Homology family PIP
Parent taxon Higher mammals
Orthologue
human House mouse
Entrez 5304 18716
Ensemble ENSG00000159763 ENSMUSG00000058499
UniProt P12273 P02816
Refseq (mRNA) NM_002652 NM_008843
Refseq (protein) NP_002643 NP_032869
Gene locus Chr 7: 143.13 - 143.14 Mb Chr 6: 41.85 - 41.85 Mb
PubMed search 5304 18716

The prolactin-induced protein (PIP, SABP, GCDFP-15) is a protein that is normally found in the saliva and other body secretions of mammals , but can also be detected in pathological changes in the mammary glands . The binding of PIP to aquaporin-5 in the salivary and lacrimal glands leads to the transport of aquaporin-5 into the apical membrane; a change in this process seems to be partly responsible for Sjogren's syndrome . The ability to bind to the Fc fragment of immunoglobulin G suggests possible immunomodulatory functions for PIP. The protein also has binding sites for actin , and it also binds to zinc-α2-glycoprotein (ZAG); related functions of the protein are not known.

The production of PIP in sperm , salivary , lacrimal and sweat glands is increased by prolactin and androgens , and slowed down by estrogen .

In pathological and neuropathological diagnostics, antibodies directed against GCDFP-15 are used as immunohistochemical diagnostic markers.

Individual evidence

  1. ↑ a b UniProt P12273
  2. ↑ Hassan MI, Bilgrami S, Kumar V, et al : Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma . In: J. Mol. Biol. . 384, No. 3, December 2008, pp. 663-72. doi : 10.1016 / j.jmb.2008.09.072 . PMID 18930737 .
  3. ↑ Ohashi Y, Tsuzaka K, Takeuchi T, Sasaki Y, Tsubota K: Altered distribution of aquaporin 5 and its C-terminal binding protein in the lacrimal glands of a mouse model for Sjogren's syndrome . In: Curr. Eye Res. . 33, No. 8, August 2008, pp. 621-9. doi : 10.1080 / 02713680802262819 . PMID 18696337 .
  4. ↑ Chiu WW, Chamley LW: Human seminal plasma prolactin-inducible protein is an immunoglobulin G-binding protein . In: J. Reprod. Immunol. . 60, No. 2, December 2003, pp. 97-111. PMID 14638438 .
  5. ↑ Mazoujian et al .: The ultrastructural localization of gross cystic disease fluid protein (GCDFP-15) in breast epithelium. In: Am J Pathol , 1984; 116 (2): 305-10. PMID 6205595
  6. ↑ Viacava et al .: Spectrum of GCDFP-15 expression in human fetal and adult normal tissues. In: Virchows Arch , 1998; 432 (3): 255-60. PMID 9532005
  7. ↑ Mazoujian et al .: Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features. At J Pathol. 1983; 110 (2): 105-12. PMID 6130702