Guanylyl cyclases
| Guanylyl cyclases | ||
|---|---|---|
| Identifier | ||
| Gene name (s) | NPR1 , NPR2 , GUCY1A2 , GUCY1A3 , GUCY1B2 , GUCY1B3 , GUCY2C , GUCY2D , GUCY2F | |
| External IDs |
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| Enzyme classification | ||
| EC, category | 4.6.1.2 , lyase | |
| Substrate | GTP | |
| Products | 3 ', 5'-cGMP + diphosphate | |
The guanylyl cyclases ( GC abbreviation , also known as guanylate cyclases ) are enzymes that catalyze the conversion of guanosine triphosphate (GTP) into 3'-5'-cyclic guanosine monophosphate ( cGMP ) with cleavage of a pyrophosphate residue .
There are soluble and membrane-bound guanylyl cyclases. In the cytosol present soluble guanylyl cyclase ( sGC -. Engl for soluble guanylyl cyclase ) is nitric oxide activated (NO) and so provides a reduction in the intracellular calcium concentration, the vasodilator effects of nitric oxide in the vascular system as well as the effect of nitric oxide as a neurotransmitter in the central Nervous system . Membrane - bound forms of guanylyl cyclase are receptors : GC-A and GC-B bind natriuretic factors such as e.g. B. the atrial natriuretic factor (ANF). GC-C is a receptor for guanylin and uroguanylin .
The guanylyl be including through calcium - ions negatively regulated.
literature
Schmidt, Thews: Human Physiology. 27th edition. P. 531