Gurmarin

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Gurmarin
Gurmarin
according to PDB  1GUR
other names

Sweet taste-suppressing peptides

Mass / length primary structure 35 amino acids , 4,232 Da
Identifier
External IDs

Gurmarin is a protein from the Gymnema sylvestre plant (also Gurmar , Hindi for 'sugar destroyer') that inhibits the sweet taste .

properties

Gurmar

Gurmarin inhibits the sweet taste, as does lactisol , gymnema acids (also from Gymnema sylvestre , but triterpene - glycosides ), ziziphin and hodulcine . Gurmarin inhibits the sweet taste in rats and humans. A 5  mM aqueous solution of Gurmarin lowers the detection limit of the human tongue for sucrose from 10 mM to 1000 mM for several hours. Gurmarin has three disulfide bridges and a pyrrolidone carboxylic acid at the N terminus . Gurmarin is found in the leaves of Gymnema sylvestre .

Individual evidence

  1. ↑ a b c d Y. Kurihara: Characteristics of antisweet substances, sweet proteins, and sweetness-inducing proteins. In: Critical reviews in food science and nutrition. Volume 32, Number 3, 1992, pp. 231-252, doi : 10.1080 / 10408399209527598 , PMID 1418601 .
  2. ↑ P. Jiang, M. Cui, B. Zhao, Z. Liu, LA Snyder, LM Benard, R. Osman, RF Margolskee, M. Max: Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. In: Journal of Biological Chemistry . Volume 280, Number 15, April 2005, pp. 15238-15246, doi : 10.1074 / jbc.M414287200 , PMID 15668251 .
  3. ↑ M. Zhao, XQ Xu, XY Meng, B. Liu: The Heptahelical Domain of the Sweet Taste Receptor T1R2 Is a New Allosteric Binding Site for the Sweet Taste Modulator Amiloride That Modulates Sweet Taste in a Species-Dependent Manner. In: Journal of molecular neuroscience: MN. [Electronic publication before printing] August 2018, doi: 10.1007 / s12031-018-1156-5 , PMID 30120716 .
  4. ↑ M. Sato: Sweet taste receptor mechanisms. In: The Japanese journal of physiology. Volume 35, Number 6, 1985, pp. 875-885, PMID 3914569 .
  5. ↑ a b Lesley Braun: Herbs and Natural Supplements Inkling. Elsevier Health Sciences, 2010, ISBN 978-0-729-57910-0 , p. 587.
  6. ↑ Gurmarin - Gymnema sylvestre (Gurmar). In: uniprot.org. October 10, 2018, accessed October 24, 2018 .