Ziziphin

Structural formula
General
Surname	Ziziphin
other names	Ziziphen
Molecular formula	C 51 H 80 O 18
External identifiers / databases
PubChem	441957
ChemSpider	390526
Wikidata	Q2363204
properties
Molar mass	981.17 g mol −1
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Ziziphine (also Ziziphen ) is a triterpene - glycoside from the Chinese date Watkins jujube that the sweet taste inhibits on the tongue of man.

properties

Chinese date

Ziziphin occurs in the leaves of Ziziphus jujuba . It inhibits the sweet taste, as does lactisol , gymnema acids , gurmarin and hodulcine . It is weaker and shorter than gymnemic acids.

literature

LM Kennedy, BP Halpern: Fly chemoreceptors: a model system for the taste modifier ziziphin. In: Physiology & behavior. Volume 24, Number 1, January 1980, pp. 135-143, PMID 7384237 .

Individual evidence

↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ Klaus Dürrschmid: Targeted modification of gustatory perception. Behr's Verlag DE, 2009, ISBN 978-3-899-47970-6 , p. 40.
↑ ^a ^b ^c Y. Kurihara: Characteristics of antisweet substances, sweet proteins, and sweetness-inducing proteins. In: Critical reviews in food science and nutrition. Volume 32, Number 3, 1992, pp. 231-252, doi : 10.1080 / 10408399209527598 , PMID 1418601 .
↑ M. Sato: Sweet taste receptor mechanisms. In: The Japanese journal of physiology. Volume 35, Number 6, 1985, pp. 875-885, PMID 3914569 .
↑ P. Jiang, M. Cui, B. Zhao, Z. Liu, LA Snyder, LM Benard, R. Osman, RF Margolskee, M. Max: Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. In: Journal of Biological Chemistry . Volume 280, Number 15, April 2005, pp. 15238-15246, doi : 10.1074 / jbc.M414287200 , PMID 15668251 .
↑ M. Zhao, XQ Xu, XY Meng, B. Liu: The Heptahelical Domain of the Sweet Taste Receptor T1R2 Is a New Allosteric Binding Site for the Sweet Taste Modulator Amiloride That Modulates Sweet Taste in a Species-Dependent Manner. In: Journal of molecular neuroscience: MN. [Electronic publication before printing] August 2018, doi: 10.1007 / s12031-018-1156-5 , PMID 30120716 .
^ AD Kinghorn, CM Compadre: Alternative Sweeteners (Third Edition, Revised and Expanded ed.) (2001). Marcel Dekker, New York. ISBN 0-8247-0437-1 .
^ VV Smith, BP Halpern: Selective suppression of judged sweetness by ziziphins. In: Physiology & behavior. Volume 30, Number 6, June 1983, pp. 867-874, PMID 6611691 .

[NV-1] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[Dürrschmid-2] Klaus Dürrschmid: Targeted modification of gustatory perception. Behr's Verlag DE, 2009, ISBN 978-3-899-47970-6 , p. 40.

[Kurihara-3] Y. Kurihara: Characteristics of antisweet substances, sweet proteins, and sweetness-inducing proteins. In: Critical reviews in food science and nutrition. Volume 32, Number 3, 1992, pp. 231-252, doi : 10.1080 / 10408399209527598 , PMID 1418601 .

[4] M. Sato: Sweet taste receptor mechanisms. In: The Japanese journal of physiology. Volume 35, Number 6, 1985, pp. 875-885, PMID 3914569 .

[5] P. Jiang, M. Cui, B. Zhao, Z. Liu, LA Snyder, LM Benard, R. Osman, RF Margolskee, M. Max: Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. In: Journal of Biological Chemistry . Volume 280, Number 15, April 2005, pp. 15238-15246, doi : 10.1074 / jbc.M414287200 , PMID 15668251 .

[6] M. Zhao, XQ Xu, XY Meng, B. Liu: The Heptahelical Domain of the Sweet Taste Receptor T1R2 Is a New Allosteric Binding Site for the Sweet Taste Modulator Amiloride That Modulates Sweet Taste in a Species-Dependent Manner. In: Journal of molecular neuroscience: MN. [Electronic publication before printing] August 2018, doi: 10.1007 / s12031-018-1156-5 , PMID 30120716 .

[Kinghorn-7] AD Kinghorn, CM Compadre: Alternative Sweeteners (Third Edition, Revised and Expanded ed.) (2001). Marcel Dekker, New York. ISBN 0-8247-0437-1 .

[8] VV Smith, BP Halpern: Selective suppression of judged sweetness by ziziphins. In: Physiology & behavior. Volume 30, Number 6, June 1983, pp. 867-874, PMID 6611691 .