HDL receptor

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HDL receptor
Properties of human protein
Mass / length primary structure 552 amino acids
Secondary to quaternary structure multipass membrane receptor
Isoforms 4th
Identifier
Gene name SCARB1
External IDs
Occurrence
Parent taxon Vertebrates

The HDL receptor (SR-BI) (also: scavenger receptor B1 ) is a protein in the cell membrane of vertebrates that binds with HDL particles and lipids . In humans, SR-BI is expressed in many types of tissue, especially in the liver , and this is the prerequisite for HDL swimming in the blood to be freed of its lipids in the liver and these can then be disposed of ( reverse cholesterol transport ). Likewise, cholesterol is required in the adrenal glands for steroid biosynthesis ; Here too, SR-BI is the docking point for HDL. Furthermore, SR-BI binds to phosphatidylserine , therefore it is involved in the phagocytosis of apoptotic cells.

SR-BI plays an essential role in infection with the hepatitis C virus and with Plasmodium parasites.

The scaffold protein PDZK1 is necessary for the expression and localization of SR-BI . The decreased expression of SR-BI in mice that were fed a high-fat diet is probably regulated by PDZK1. In the adrenal glands, the expression of SR-BI is regulated with signal transduction via PREB .

Individual evidence

  1. ↑ Homologues at OMA
  2. ↑ UniProt Q8WTV0
  3. ↑ Dreux M, Dao Thi VL, Fresquet J, et al. : Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra- and extra-cellular domains . In: PLoS Pathog . . 5, No. 2, February 2009, p. E1000310. doi : 10.1371 / journal.ppat.1000310 . PMID 19229312 . PMC 2636890 (free full text).
  4. ↑ Connelly MA: SR-BI-mediated HDL cholesteryl ester delivery in the adrenal gland . In: Mol. Cell. Endocrinol. . 300, No. 1-2, March 2009, pp. 83-8. doi : 10.1016 / j.mce.2008.09.011 . PMID 18840501 .
  5. ↑ Jia ZS, Du DW, Lei YF, et al. : Scavenger receptor class B type I mediates cell entry of hepatitis C virus . In: J Int Med Res . 36, No. 6, 2008, pp. 1319-25. PMID 19094442 .
  6. ↑ Yalaoui S, Huby T, Franetich JF, et al. : Scavenger receptor BI boosts hepatocyte permissiveness to Plasmodium infection . In: Cell Host Microbe . 4, No. 3, September 2008, pp. 283-92. doi : 10.1016 / j.chom.2008.07.013 . PMID 18779054 .
  7. ↑ Fenske SA, Yesilaltay A, Pal R, et al. : Normal hepatic cell surface localization of the high density lipoprotein receptor, scavenger receptor class B, type I, depends on all four PDZ dmains of PDZK1 . In: J. Biol. Chem. . 284, No. 9, February 2009, pp. 5797-806. doi : 10.1074 / jbc.M808211200 . PMID 19116202 .
  8. ↑ Niemeier A, Kovacs WJ, Strobl W, Stangl H: Atherogenic diet leads to posttranslational down-regulation of murine hepatocyte SR-BI expression . In: Atherosclerosis . 202, No. 1, January 2009, pp. 169-75. doi : 10.1016 / j.atherosclerosis.2008.04.018 . PMID 18513727 .
  9. ↑ Zhu W, Saddar S, Seetharam D, et al. : The scavenger receptor class B type I adapter protein PDZK1 maintains endothelial monolayer integrity . In: Circ. Res. . 102, No. 4, February 2008, pp. 480-7. doi : 10.1161 / CIRCRESAHA.107.159079 . PMID 18174467 .
  10. ↑ Murao K, Imachi H, Yu X, et al. : The transcriptional factor prolactin regulatory element-binding protein mediates the gene transcription of adrenal scavenger receptor class B type I via 3 ', 5'-cyclic adenosine 5'-monophosphate . In: Endocrinology . 149, No. 12, December 2008, pp. 6103-12. doi : 10.1210 / en.2008-0380 . PMID 18755803 .

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