Henri Laborit
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Henri Marie Laborit (born November 21, 1914 in Hanoi ( Vietnam ), † May 18, 1995 in Paris ) was a French military doctor , neurologist , surgeon and chemist .
Life
Laborit was a researcher at the naval base in Toulon ( southern France ) and later a professor at the University of Québec . He mainly researched the autonomic nervous system , anesthesia and carried out experiments with sedatives .
He became known as one of the discoverers of the first known psychotropic drug chlorpromazine . With a "lytic cocktail" Laborit tried to alleviate the stress that occurs during major operations. In 1949 this mixture contained procaine , curare , TEA, atropine and atosil . Since Laborit particularly noticed the importance of the antihistamine effect, he recommended further research in this direction. In December 1950, chlorpromazine was synthesized. In February 1952 Laborit published the first report on chlorpromazine as the main subject. However, since Laborit was mainly concerned with the use of chlorpromazine in surgery in mentally healthy people, its importance for the treatment of psychoses is controversial.
Laborit was nominated for the Nobel Prize in 1957 , but did not receive it. For this he received the Albert Lasker Award for Clinical Medical Research (also known as the "American Nobel Prize").
Laborit also discovered the neurotransmitter gamma-aminobutyric acid .
Alain Resnais's 1980 film My Uncle from America (original: Mon oncle d'Amérique ) is about his theses . Laborit plays himself here and was involved in the script.
literature
- Hans Bangen: History of the drug therapy of schizophrenia . Berlin 1992. Pages 73-80 The synthesis of chlorpromazine , ISBN 3-927408-82-4
- Henri Laborit: Sodium 4-hydroxybutyrate . In: International Journal of Neuropharmacology . Volume 3, No. 4, 1964, pp. 433-452.
- Henri Laborit: Éloge de la fuite , 1976
See also
Neuroleptics , psychotropic drugs
Web links
- infoamerica.org (biography in Spanish)
- Henri Laborit in the Internet Movie Database (English)
| personal data | |
|---|---|
| SURNAME | Laborit, Henri |
| ALTERNATIVE NAMES | Laborit, Henri Marie |
| BRIEF DESCRIPTION | French neurologist, doctor and chemist |
| DATE OF BIRTH | November 21, 1914 |
| PLACE OF BIRTH | Hanoi , Vietnam |
| DATE OF DEATH | May 18, 1995 |
| Place of death | Paris |