Hepatic triglyceride lipase
| Hepatic triglyceride lipase | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 477 amino acids | |
| Cofactor | Heparin | |
| Identifier | ||
| Gene name | LIPC | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.1.1.3 , lipases | |
| Response type | hydrolysis | |
| Substrate | Triacylglycerol + H 2 O | |
| Products | Diacylglycerol + fatty acid | |
| Occurrence | ||
| Homology family | Lipoprotein lipase | |
| Parent taxon | Euteleostomi | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 3990 | 15450 |
| Ensemble | ENSG00000166035 | ENSMUSG00000032207 |
| UniProt | P11150 | P27656 |
| Refseq (mRNA) | NM_000236 | NM_008280 |
| Refseq (protein) | NP_000227 | NP_032306 |
| Gene locus | Chr 15: 58.41 - 58.57 Mb | Chr 9: 70.8 - 70.93 Mb |
| PubMed search | 3990 |
15450
|
The hepatic lipase (HTGL, LIPC) is a human enzyme which the capillaries is localized to the liver. HTGL is counted among the lipolytic (fat-degrading) enzymes. Specifically, it breaks down fats such as triglycerides , which are transported in the blood in lipoproteins , and the lipoprotein HDL2 through the biochemical mechanism of hydrolysis . The breakdown of triglycerides releases fatty acids that the body uses as a source of energy. Mutations in the HTGL gene can lead to a rare hereditary deficiency disease.
After administration of anticoagulant heparins (these are used, among other things, to prevent and treat thrombosis), the HTGL appears in the circulating blood. Other lipolytic enzymes are, for example, lipoprotein lipase and lecithin cholesterol acyltransferase (LCAT).
swell
- ↑ UniProt entry
- ↑ Lothar Thomas (ed.): Labor and diagnosis. TH-Books, Frankfurt 2008. p. 238.
