Homeobox protein DLX-3

from Wikipedia, the free encyclopedia
Homeobox protein DLX-3
Properties of human protein
Mass / length primary structure 287 amino acids
Identifier
Gene name DLX3
External IDs
Occurrence
Parent taxon Vertebrates

The homeobox protein DLX-3 ( gene name: DLX3 ) is a protein found in the cell nuclei of vertebrate cells . As a transcription factor , it is mainly expressed during the development of the forebrain . It may also take part in the morphogenesis of the skull. Mutations in the DLX3 gene have been linked to the autosomal dominant conditions of tricho-dento-osseous syndrome and amelogenesis imperfecta with taurodontism .

Many vertebrate genes containing homeobox have been identified by their sequence similarity to the developmental genes of Drosophila . Members of the DLX gene family contain a homeobox that is related to the "distal-less" (Dll), a gene that is expressed in the head and limbs of a developing fruit fly. The “Distal-less” gene family (Dlx) comprises at least six different members, DLX1 - DLX6 . The gene is in a configuration with other members of the gene family on the long arm of chromosome 17 .

Web links

literature

  • Morasso MI, Radoja N: Dlx Genes, p63, and Ectodermal Dysplasias . In: Birth Defects Res. C Embryo Today . 75, No. 3, 2005, pp. 163-71. doi : 10.1002 / bdrc.20047 . PMID 16187309 . PMC 1317295 (free full text).
  • Bonaldo MF, Lennon G, Soares MB: Normalization and subtraction: two approaches to facilitate gene discovery . In: Genome Res. . 6, No. 9, 1997, pp. 791-806. doi : 10.1101 / gr.6.9.791 . PMID 8889548 .
  • S. Nakamura, DW Stock, KL Wydner, JA Bollekens, K. Takeshita, BM Nagai, S. Chiba, T. Kitamura, TM Freeland, Z. Zhao, J. Minowada, JB Lawrence, KM Weiss, FH Ruddle: Genomic analysis of a new mammalian distal-less gene: Dlx7. In: Genomics. Volume 38, Number 3, December 1996, ISSN  0888-7543 , pp. 314-324, doi : 10.1006 / geno.1996.0634 . PMID 8975708 .
  • JA Price, DW Bowden, JT Wright, MJ Pettenati, TC Hart: Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome. In: Human Molecular Genetics . Volume 7, number 3, March 1998, ISSN  0964-6906 , pp. 563-569, doi : 10.1093 / hmg / 7.3.563 , PMID 9467018 .
  • MS Roberson, S. Meermann, MI Morasso, JM Mulvaney-Musa, T. Zhang: A role for the homeobox protein Distal-less 3 in the activation of the glycoprotein hormone alpha subunit gene in choriocarcinoma cells. In: The Journal of biological chemistry. Volume 276, Number 13, March 2001, ISSN  0021-9258 , pp. 10016-10024, doi : 10.1074 / jbc.M007481200 . PMID 11113121 .
  • GT Park, MF Denning, MI Morasso: Phosphorylation of murine homeodomain protein Dlx3 by protein kinase C. In: FEBS letters. Volume 496, number 1, May 2001, ISSN  0014-5793 , pp. 60-65, doi : 10.1016 / S0014-5793 (01) 02398-5 , PMID 11343707 , PMC 1283141 (free full text).
  • L. Peng, AH Payne: AP-2 gamma and the homeodomain protein distal-less 3 are required for placental-specific expression of the murine 3 beta-hydroxysteroid dehydrogenase VI gene, Hsd3b6. In: The Journal of biological chemistry. Volume 277, Number 10, March 2002, ISSN  0021-9258 , pp. 7945-7954, doi : 10.1074 / jbc.M106765200 . PMID 11773066 .
  • K. Sumiyama, SQ Irvine, DW Stock, KM Weiss, K. Kawasaki, N. Shimizu, CS Shashikant, W. Miller, FH Ruddle: Genomic structure and functional control of the Dlx3-7 bigene cluster. In: Proceedings of the National Academy of Sciences . Volume 99, Number 2, January 2002, ISSN  0027-8424 , pp. 780-785, doi : 10.1073 / pnas.012584999 . PMID 11792834 , PMC 117382 (free full text).
  • RL Strausberg, EA Feingold, et al .: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. In: Proceedings of the National Academy of Sciences . Volume 99, Number 26, December 2002, ISSN  0027-8424 , pp. 16899-16903, doi : 10.1073 / pnas.242603899 . PMID 12477932 , PMC 139241 (free full text).
  • H. Imabayashi, T. Mori, S. Gojo, T. Kiyono, T. Sugiyama, R. Irie, T. Isogai, J. Hata, Y. Toyama, A. Umezawa: Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. In: Experimental cell research. Volume 288, Number 1, August 2003, ISSN  0014-4827 , pp. 35-50, doi : 10.1016 / S0014-4827 (03) 00130-7 , PMID 12878157 .
  • MP Holland, SP Bliss, KA Berghorn, MS Roberson: A role for CCAAT / enhancer-binding protein beta in the basal regulation of the distal-less 3 gene promoter in placental cells. In: Endocrinology. Volume 145, Number 3, March 2004, ISSN  0013-7227 , pp. 1096-1105, doi : 10.1210 / en.2003-0777 . PMID 14670999 .
  • RJ Haldeman, LF Cooper, TC Hart, C. Phillips, C. Boyd, GE Lester, JT Wright: Increased bone density associated with DLX3 mutation in the tricho-dento-osseous syndrome. In: Bone. Volume 35, Number 4, October 2004, ISSN  8756-3282 , pp. 988-997, doi : 10.1016 / j.bone.2004.06.003 . PMID 15454107 .
  • DS Gerhard, L. Wagner, et al .: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). In: Genome research. Volume 14, number 10B, October 2004, ISSN  1088-9051 , pp. 2121-2127, doi : 10.1101 / gr.2596504 . PMID 15489334 , PMC 528928 (free full text).
  • J. Dong, D. Amor, MJ Aldred, T. Gu, M. Escamilla, M. MacDougall: DLX3 mutation associated with autosomal dominant amelogenesis imperfecta with taurodontism. In: American journal of medical genetics. Part A. Volume 133A, Number 2, March 2005, ISSN  1552-4825 , pp. 138-141, doi : 10.1002 / ajmg.a.30521 . PMID 15666299 .
  • M. Islam, AG Lurie, E. Reichenberger: Clinical features of tricho-dento-osseous syndrome and presentation of three new cases: an addition to clinical heterogeneity. In: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. Volume 100, Number 6, December 2005, ISSN  1528-395X , pp. 736-742, doi : 10.1016 / j.tripleo.2005.04.017 . PMID 16301156 .
  • T. Otsuki, T. Ota, et al .: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. In: DNA research: an international journal for rapid publication of reports on genes and genomes. Volume 12, number 2, 2005, ISSN  1756-1663 , pp. 117-126, doi : 10.1093 / dnares / 12.2.117 . PMID 16303743 .
  • C. Morsczeck: Gene expression of runx2, Osterix, c-fos, DLX-3, DLX-5, and MSX-2 in dental follicle cells during osteogenic differentiation in vitro. In: Calcified tissue international. Volume 78, Number 2, February 2006, ISSN  0171-967X , pp. 98-102, doi : 10.1007 / s00223-005-0146-0 . PMID 16467978 .
  • KA Berghorn, PA Clark-Campbell, L. Han, M. McGrattan, RS Weiss, MS Roberson: Smad6 represses Dlx3 transcriptional activity through inhibition of DNA binding. In: The Journal of biological chemistry. Volume 281, Number 29, July 2006, ISSN  0021-9258 , pp. 20357-20367, doi : 10.1074 / jbc.M603049200 . PMID 16687405 .

Individual evidence

  1. ↑ Orthologist at OMA
  2. ↑ SW Scherer, HH Heng, GW Robinson, KA Mahon, JP Evans, LC Tsui: Assignment of the human homolog of mouse Dlx3 to chromosome 17q21.3-q22 by analysis of somatic cell hybrids and fluorescence in situ hybridization . In: Mamm Genome . 6, No. 4, August 1995, pp. 310-311. doi : 10.1007 / BF00352432 . PMID 7613049 .
  3. ↑ Entrez Gene: DLX3 distal-less homeobox 3 . Retrieved May 20, 2012.
  4. ↑ UniProt O60479