Immucillin-H

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Structural formula
Structure of Immucillin-H
General
Non-proprietary name Forodesin
other names

Immucillin-H

Molecular formula C 11 H 14 N 4 O 4
External identifiers / databases
CAS number
  • 209799-67-7
  • 284490-13-7 (forodesin hydrochloride)
PubChem 444499
ChemSpider 392417
DrugBank DB06185
Wikidata Q410040
Drug information
Drug class

Antiviral agent , nucleoside reverse transcriptase inhibitors

properties
Molar mass 266.25 g mol −1
safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Immucillin-H , Forodesin INN (manufacturer: BioCryst Pharmaceuticals) is a new type of active ingredient for the targeted therapy of malignant haematological diseases, in particular acute T-cell leukemia (T-ALL) . Immucillin-H belongs to the group of PNP inhibitors and is currently being tested for its safety and effectiveness in various clinical studies .

Mechanism of action

Immucillin-H inhibits the function of the enzyme purine nucleoside phosphorylase ( PNP ) and thus leads to a selective reduction in T lymphocytes in the patient's blood.

Indications

Adults

For Immucillin-H, the following indications are currently being investigated in initial clinical studies (phase II) :

literature

  • Gandhi V. et al. (2005): A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine). Blood 106 (13); 4253-4260; PMID 16131572 ; PDF (free full text access)

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

Web links