Ingrid Grummt

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Ingrid Grummt (born November 26, 1943 ) is a German molecular and cell biologist. She holds a Helmholtz Professorship for Molecular Biology at the German Cancer Research Center (DKFZ) in Heidelberg .

Ingrid Grummt studied biology at the Humboldt University in Berlin from 1962, graduating in 1967 and gaining a doctorate in 1970. She was a post-doctoral student at the German Academy of Sciences in Berlin and from 1972 at the Max Planck Institute for Biochemistry in Munich. In 1977 she completed her habilitation at the University of Munich and from 1980 to 1984 she headed a research group at the Institute for Biochemistry at the University of Würzburg. From 1985 to 1989 she was Professor of Microbiology in Würzburg and from 1989 she was head of department at the German Cancer Research Center in Heidelberg. From 1992 to 2005 she was on the DKFZ Board of Trustees.

She is concerned with gene regulation in mammalian cells, in particular the mechanism by which external environmental signals change the transcription of the cell's genome. This also includes misdirected gene expression processes as in cancer or other diseases.

In addition, she deals with epigenetic control mechanisms of gene expression, which work, for example, by changing the structure of chromatin , the DNA-protein complex in the chromosomes that protects DNA. Changes to the chromatin can, however, prevent or enable certain gene segments to be read out. She was able to demonstrate that non-coding RNA (ncRNA) play an important role in epigenetic gene regulation . They ensure that regulatory gene regions can be blocked by methylation. Grummt is also investigating the role of these epigenetic mechanisms in cancer (difference between methylation patterns in normal and cancer cells).

She discovered a protein complex (NoRC) that silences ribosomal genes by packing them more tightly. The deactivation of these genes plays a role in aging processes and hereditary diseases.

In 1990 she received the Gottfried Wilhelm Leibniz Prize and in 2013 the Schleiden Medal of the Leopoldina. In 2008 she received an ERC Advanced Grant. She is a member of the Leopoldina and the Academia Europaea . She has been a member of the European Molecular Biology Organization (EMBO) since 1985 and was on its council from 2002 to 2007. In 2010 she received the Women in Science Award from FEBS and EMBO. In 2012 she was awarded the Prix ​​International de l'INSERM .

Web links

Individual evidence

  1. ↑ http://www.leopoldina.org/fileadmin/redaktion/Mitglieder/CV_Grummt_Ingrid_D.pdf
  2. ↑ Ingrid Grummt's member entry at the German Academy of Natural Scientists Leopoldina , accessed on October 23, 2015.
  3. ^ Announcement from the DKFZ 2010
personal data
SURNAME Grumble, Ingrid
BRIEF DESCRIPTION German cell and molecular biologist
DATE OF BIRTH November 26, 1943