Insulin receptor substrate
| Insulin receptor substrate | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 552 amino acids | |
| Secondary to quaternary structure | Homodimer | |
| Isoforms | 6th | |
| Identifier | ||
| Gene name | BAIAP | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Vertebrates | |
The insulin receptor substrate (IRSp53) (also: brain-specific angiogenesis-inhibitor 1-associated protein 2 (BAP2) , gene name: BAIAP2 ) is a structural protein in vertebrates . As a cytoskeletal adapter , it binds to membrane-bound small G proteins and cytoplasmic effector proteins at the same time . His presence is necessary in the reorganization and regulation of the actin - cytoskeleton as well as the growth of neurites and filopodia .
By binding the IRS to a phosphorus tyrosine domain of the activated insulin receptor and phosphorylation of the IRS by the kinase activity of the receptor, other signal transduction molecules bind to the IRS. The most important additional signal transduction molecule for the action of insulin is the PI3 kinase .
literature
- A. Yamagishi, M. Masuda, et al. a .: A novel actin bundling / filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. In: The Journal of biological chemistry . Volume 279, Number 15, April 2004, pp. 14929-14936. doi : 10.1074 / jbc.M309408200 . PMID 14752106 .
- A. Disanza, S. Mantoani, et al. a .: Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex. In: Nature cell biology . Volume 8, Number 12, December 2006, pp. 1337-1347, ISSN 1465-7392 . doi : 10.1038 / ncb1502 . PMID 17115031 .
- T. Takenawa, S. Suetsugu: The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. In: Nature Reviews Molecular Cell Biology . Volume 8, Number 1, January 2007, pp. 37-48, ISSN 1471-0072 . doi : 10.1038 / nrm2069 . PMID 17183359 . (Review).
- S. Govind, R. Kozma, et al. a .: Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin. In: Journal of Cell Biology . Volume 152, Number 3, February 2001, pp. 579-594, ISSN 0021-9525 . PMID 11157984 . PMC 2195994 (free full text).
- PK Mattila, P. Lappalainen: Filopodia: molecular architecture and cellular functions. In: Nature reviews. Molecular cell biology. Volume 9, Number 6, June 2008, pp. 446-454, ISSN 1471-0080 . doi : 10.1038 / nrm2406 . PMID 18464790 . (Review).
Individual evidence
- ↑ InterPro : IPR013606 (English)
- ↑ UniProt Q9UQB8
- ^ TH Millard, G. Bompard et al. a .: Structural basis of filopodia formation induced by the IRSp53 / MIM homology domain of human IRSp53. In: The EMBO journal . Volume 24, Number 2, January 2005, pp. 240-250. doi : 10.1038 / sj.emboj.7600535 . PMID 15635447 . PMC 545821 (free full text).