Integrin α-2
| Integrin alpha-2 | ||
|---|---|---|
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| according to PDB 1AOX , in 2 views | ||
| other names |
CD49 antigen-like family member B, collagen receptor, platelet membrane glycoprotein Ia, GPIa |
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| Properties of human protein | ||
| Mass / length primary structure | 1,181 amino acids , 129,295 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 3673 | |
| Ensemble | ENSG00000164171 | |
| UniProt | P17301 | |
| Refseq (mRNA) | NM_002203.3 | |
| Refseq (protein) | NP_002194.2 | |
| PubMed search |
3673
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Integrin α-2 (synonym CD49b ) is a surface protein from the group of integrins .
properties
Integrin α-2 is a cell adhesion molecule . Together with integrin beta-1 it forms a heterodimeric receptor for laminin , collagen and its C- propeptides , fibronectin and E-cadherin . Integrin α-2 binds to the amino acid sequence GlyPheHypGlyAspArg in collagen. It inhibits the activity of the EGF receptor . Integrin α-2 is glycosylated . It is involved in the cell adhesion of platelets and other cells to collagens. It modulates the gene expression of collagens and collagenases . The protein complex of integrin α-2 and β-1 is also the receptor for the human rotavirus and human ECHO viruses of types 1 and 8.
Web links
Individual evidence
- ↑ A. Madamanchi, SA Santoro, MM Zutter: α2β1 integrin. In: Advances in Experimental Medicine and Biology . Volume 819, 2014, pp. 41-60, doi : 10.1007 / 978-94-017-9153-3_3 , PMID 25023166 .
- ↑ Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA: Structural analysis of the alpha (2) integrin I domain / procollagenase-1 (matrix metalloproteinase-1) interaction . In: J. Biol. Chem. . 276, No. 31, Aug 2001, pp. 29375-81. doi : 10.1074 / jbc.M102217200 . PMID 11359774 .
- ↑ Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC: Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha (2) beta (1) integrin upon release from keratinocytes migrating on type I collagen . In: J. Biol. Chem. . 276, No. 31, Aug 2001, pp. 29368-74. doi : 10.1074 / jbc.M104179200 . PMID 11359786 .