Interconversion
Under interconversion (synonymous with interconversion) is the change in the activity state of an enzyme / compound, so the activation or even inactivation, for example. By attaching or removing a phosphate to a free OH-group of the enzyme (for example, disassembly, phosphorylation ) by means of Protein kinases or phosphatases . Another concrete example of interconversion would be the conversion of active cortisol into inactive cortisone by 11β-hydroxysteroid dehydrogenase 1 . Functionally, I change a group of a protein / compound enzymatically and thereby achieve an (in) activation of the protein / compound in question.
A distinction must be made here between the fact that some enzymes are phosphorylated, but others are active in the dephosphorylated state.
The amount of active enzymes can thus be changed, with the enzyme kinetic parameters K m and V max also changing and thus several metabolic pathways being able to be regulated at the same time (especially in the case of hormone-controlled metabolic pathways).
Examples:
- Glycolysis enzymes are dephosphorylated
- Enzymes of gluconeogenesis are phosphorylated active
- Pyruvate dehydrogenase (PDH), which is also regulated allosterically