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Belt model according to PDB  2H24

Existing structural data : 1ilk , 1inr , 1j7v , 1lk3 , 1vlk , 1y6k , 1y6m , 1y6n , 2h24 , 2ilk

Properties of human protein
Mass / length primary structure 160 amino acids
Secondary to quaternary structure Homodimer
Gene names IL10  ; CSIF; IL-10; IL10A; MGC126450; MGC126451; TGIF
External IDs
Parent taxon Tissue animals , some viruses
human House mouse
Entrez 3586 16153
Ensemble ENSG00000136634 ENSMUSG00000016529
UniProt P22301 P18893
Refseq (mRNA) NM_000572 NM_010548
Refseq (protein) NP_000563 NP_034678
Gene locus Chr 1: 206.77 - 206.77 Mb Chr 1: 131.02 - 131.02 Mb
PubMed search 3586 16153

Interleukin-10 (or IL10 for short , or outdated: Cytokine-synthesis inhibitory factor or CSIF for short ) belongs to the interleukins within the cytokines (messenger substances of the immune system) . It is mainly secreted by monocytes and also by TH2 lymphocytes . It has numerous functions in the regulation of the immune system. Among other things, it has a limiting and inhibiting effect on defense processes that affect z. B. can lead to septic shock and thus protects the organism from destroying itself through excessive inflammatory processes. Together with TGF-β it is one of the most important anti- inflammatory cytokines and is important for the development of immune tolerance . It inhibits the formation of cytokines of the Th1 response and has a prolonged effect on the survival, reproduction and antibody production of B lymphocytes . It blocks the nuclear factor NF-κB and is involved in the regulation of the JAK-STAT signaling pathway . Interleukin-10 is an essential immunomodulator in the intestinal tract. Deficiency is associated with a predisposition to inflammatory bowel diseases such as Crohn's disease or ulcerative colitis .


The precursor of interleukin-10 is encoded in humans on chromosome 1 gene locus q31-32. The gene product comprises 178 amino acids.



  • TH Sky Ng, Graham J. Britton, et al. a .: Regulation of Adaptive Immunity; The role of interleukin-10. In: Frontiers in Immunology. 4, 2013, S., doi : 10.3389 / fimmu.2013.00129 .

Individual evidence

  1. InterPro : IPR000098 Interleukin-10 (English)
  2. ^ Grütz, G. (2005): New insights into the molecular mechanism of Interleukin-10-mediated immunosupression. ( Memento of the original from December 1, 2008 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Journal of Leukocyte Biology , Volume 77, January 2005: 3-15. @1@ 2Template: Webachiv / IABot /

Web links