Isopentenyl diphosphate isomerase
| Isopentenyl diphosphate isomerase | ||
|---|---|---|
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Existing structural data: s. UniProt |
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| Mass / length primary structure | 227 amino acids | |
| Secondary to quaternary structure | Monomer | |
| Cofactor | Mg 2+ | |
| Isoforms | 1.2 | |
| Identifier | ||
| Gene name (s) | IDI1 , IDI2 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 5.3.3.2 , isomerase | |
| Response type | Rearrangement | |
| Substrate | IPP | |
| Products | DMAPP | |
| Occurrence | ||
| Parent taxon | Creature | |
Isopentenyl diphosphate isomerases (IPPI) are enzymes that catalyze the rearrangement of isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP) and vice versa. They occur in all living things. There are two non-homologous types of IPPI, type I occurs only in eukaryotes and some bacteria , while the FMN- dependent type is found in bacteria and archaea . For animals, the reaction step is important for cholesterol biosynthesis . There are two isoforms in humans, the second of which only occurs in muscles .
Catalyzed reaction
⇔ 
Isopentenyl diphosphate (IPP) and dimethyl allyl diphosphate (DMAPP) merge.
Individual evidence
- ↑ Interpro: IPPI, Type 1
- ↑ InterPro: IPPI, FMN-dependent
- ↑ Rothman SC, Helm TR, Poulter CD: Kinetic and spectroscopic characterization of type II isopentenyl diphosphate isomerase from Thermus thermophilus: evidence for formation of substrate-induced flavin species . In: Biochemistry . 46, No. 18, May 2007, pp. 5437-5445. doi : 10.1021 / bi0616347 . PMID 17428035 . PMC 2516918 (free full text).
- ↑ Clizbe DB, Owens ML, Masuda KR, Shackelford JE, Krisans SK: IDI2, a second isopentenyl diphosphate isomerase in mammals . In: J. Biol. Chem. . 282, No. 9, March 2007, pp. 6668-6676. doi : 10.1074 / jbc.M610922200 . PMID 17202134 .
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Cholesterol Biosynthesis - Learning and Teaching Materials
- Jassal / reactome: Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate