Isoxazole

Structural formula
General
Surname	Isoxazole
other names	1,2-oxazole
Molecular formula	C 3 H 3 NO
External identifiers / databases
CAS number 288-14-2 EC number 206-018-7 ECHA InfoCard 100.005.472 PubChem 9254 Wikidata Q899683
properties
Molar mass	69.06 g mol −1
Physical state	liquid
density	1.078 g cm −3 (25 ° C)
boiling point	93-95 ° C
Refractive index	1,427
safety instructions
GHS labeling of hazardous substances danger H and P phrases H: 225 P: 210
Thermodynamic properties
ΔH f 0	42.1 kJ / mol
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

Isoxazole is a nitrogen-containing heterocycle derived from furan and pyrrole . In contrast to the isomeric oxazole , the oxygen atom is next to the nitrogen.

Isoxazole rings are found in some natural products such as B. Ibotenic acid . Isoxazoles are also the basis for a number of drugs, e.g. B. the COX-2 inhibitor valdecoxib (Bextra).

Individual evidence

1. ↑ ^{a b c d e} Isoxazole data sheet from Sigma-Aldrich , accessed on July 14, 2011 ( PDF ).
2. ↑ David R. Lide (Ed.): CRC Handbook of Chemistry and Physics . 90th edition. (Internet version: 2010), CRC Press / Taylor and Francis, Boca Raton, FL, Standard Thermodynamic Properties of Chemical Substances, pp. 5-23.