Isoxazole
Structural formula | ||||||||||||||||
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General | ||||||||||||||||
Surname | Isoxazole | |||||||||||||||
other names |
1,2-oxazole |
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Molecular formula | C 3 H 3 NO | |||||||||||||||
External identifiers / databases | ||||||||||||||||
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properties | ||||||||||||||||
Molar mass | 69.06 g mol −1 | |||||||||||||||
Physical state |
liquid |
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density |
1.078 g cm −3 (25 ° C) |
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boiling point |
93-95 ° C |
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Refractive index |
1,427 |
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safety instructions | ||||||||||||||||
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Thermodynamic properties | ||||||||||||||||
ΔH f 0 |
42.1 kJ / mol |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C |
Isoxazole is a nitrogen-containing heterocycle derived from furan and pyrrole . In contrast to the isomeric oxazole , the oxygen atom is next to the nitrogen.
Isoxazole rings are found in some natural products such as B. Ibotenic acid . Isoxazoles are also the basis for a number of drugs, e.g. B. the COX-2 inhibitor valdecoxib (Bextra).
Individual evidence
- ↑ a b c d e Isoxazole data sheet from Sigma-Aldrich , accessed on July 14, 2011 ( PDF ).
- ↑ David R. Lide (Ed.): CRC Handbook of Chemistry and Physics . 90th edition. (Internet version: 2010), CRC Press / Taylor and Francis, Boca Raton, FL, Standard Thermodynamic Properties of Chemical Substances, pp. 5-23.