James M. Bobbitt

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James M. Bobbitt (2019)

James M. Bobbitt (born January 18, 1930 in Charleston , West Virginia ) is an American chemist and professor.

Life

James M. Bobbitt was born in Charleston, West Virginia in 1930, where he received his Bachelor of Science degree from West Virginia University in 1951 . He moved to Ohio State University , and in 1955 - under the supervision of ML Wolfrom - was awarded a Ph.D. PhD . During his time at Ohio State University, he worked from 1952 to 1955 as a teaching assistant. As a postdoc , he then moved to Wayne State University to do research in Carl Djerassi's group for a year . From 1956 he worked as a lecturer at the University of Connecticut , where he finally worked as a professor from 1969 to 1991. In 1992 he became professor emeritus - also at the University of Connecticut . In addition, he was acting head of department from 1976 to 1977 and head of department from 1977 to 1982 at the University of Connecticut and was able to work as a PhD employee for one year at the University of Zurich with Hans Schmid from 1959 to 1960 . Bobbitt also worked as a visiting professor at several universities: from 1964 to 1965 at the University of East Anglia under the direction of Alan R. Katritzky , in June 1968 at the University of Kiel , in June 1971 at Tohoku University in Japan, from 1971 to 1972 at La Trobe University in Australia and from 1980 to 1981 at the University of Adelaide - also in Australia. Bobbitt is also a member of the American Chemical Society , the Sigma Xi , the Phi Beta Kappa , the Phi Lambda Upsilon, the Chemical Society (London) and the Electrochemical Society. Bobbitt was also a member of several boards and committees. These include, in 1962, the selection committee of the NSF Cooperative Predoctoral Program of the National Academy of Sciences in Washington, DC , from 1965 to 1968 the Carbohydrates Subcommittee (Committee on Biological Chemistry) of the National Academy of Sciences, and in 1968 the professor-in-charge , a course called Thin-Layer Chromatography from the American Chemical Society. In 1970 he became President of the UCONN Chapter at Sigma Xi and from 1974 to 1975 he was Vice-Presidency and President of the UCONN Chapter at Phi Beta Kappa.

research

Bobbitt Salt

James M. Bobbitt is the author of 11 books and 120 research articles. In his research he specialized in alkaloids , preparative electrochemistry and oxidation chemistry . He showed additional research interest in the synthesis of nitrogen heterocycles, thin layer chromatography , electrolytic oxidation and the oxoammonium salt oxidation of alcohols with stoichiometric amounts of the recyclable Bobbitt salt .

The Bobbitt reaction for the synthesis of tetrahydroisoquinoline and its derivatives , which he discovered in 1965, also attracted particular attention .

Selection of important publications

  • James M. Bobbitt: Thin-layer Chromatography. Reinhold Publishing Co., New York 1963.
  • James M. Bobbitt, C. Brückner, N. Merbouh: Oxoammonium salt and nitroxide catalyzed oxidations of alcohols. In: Organic Reactions. Volume 74, 2009, pp. 103-424.
  • ML Wolfrom, James M. Bobbitt: Periodate oxidation of cyclic 1,3, -diketones. In: J. Am. Chem. Soc. Volume 78, 1956, p. 2489.
  • C. Djerassi, SK Figdor, James M. Bobbitt, FI Markley: Alkaloid studies. XIV. The structure of the cactus alkaloid piloceriene. In: J. Am. Chem. Soc. Volume 78, 1956, p. 3861.
  • James M. Bobbitt: Regeneration of alkaloids from their picrates with an anion-exchange resin. In: J. Org. Chem. Volume 22, 1957, p. 1729.
  • James M. Bobbitt, LH Amundsen, RI Steiner. Amination reactions of cis ‑ 1,4 ‑ dichloro ‑ 2 ‑ butenes. In: J. Org. Chem. Volume 25, 1960, p. 2230.
  • James M. Bobbitt, DP Winter, JM Kiely: Synthesis of isoquinolines. IV. 4-benzylisoquinolines. In: J. Org. Chem. Volume 30, 1965, p. 2459.
  • James M. Bobbitt, JM Kiely, KL Khanna, R. Eberman: Synthesis of isoquinolines. III. A new synthesis of 1,2,3,4-tetrahydroisoquinolines. In: J. Org. Chem. Volume 30, 1965, p. 2247.
  • James M. Bobbitt, DN Roy, A. Marchand, CW Allen: Synthesis of isoquinolines. VI. N ‑ alkyl ‑ 1,2,3,4 ‑ tetrahydroisoquinolines. In: J. Org. Chem. Volume 32, 1967, p. 2225.
  • James M. Bobbitt, JC Sih: Synthesis of isoquinolines. VII. 4 ‑ hydroxy ‑ 1,2,3,4 ‑ tetrahydroisoquinolines. In: J. Org. Chem. Volume 33, 1968, pp. 856-859.
  • James M. Bobbitt, AP Katritzky, RD Kennewell, M. Snarey. Steric requirements of sp2 ‑ hybridized lone electron pairs. Part I. The conformation of 2‑ (pyridylmethylene) indan ‑ 1 ‑ ones. In: J. Chem. Soc. (B). 1968, pp. 550-553.
  • James M. Bobbitt, AS Steinfeld, KH Weisgraber, S. Dutta: Synthesis of isoquinolines. X. 1 ‑ alkyl ‑ 1,2,3,4 ‑ tetrahydroisoquinilines. In: J. Org. Chem. Volume 34, 1969, p. 2478.
  • James M. Bobbitt, I. Noguchi, H. Yage, KH Weisgraber: Electrochemistry of natural products. III. A stereoselective, stereospecific phenol coupling reaction. In: J. Am. Chem. Soc. Volume 93, 1971, p. 3551.
  • James M. Bobbitt, SJ Huang: A simulated research project in synthetic organic chemistry. An undergraduate laboratory. In: J. Chem. Educ. Volume 51, 1974, p. 58.
  • James M. Bobbitt, IGC Coutts, MR Hamblin, EJ Tinley: The enzymatic oxidation of phenolic tetrahydroisoquinoline-1-carboxylic acids. In: J. Chem. Soc., Perkin Trans. I. 1979, pp. 2744-2749.
  • James M. Bobbitt, AJ Bourque: Syntheses of heterocycles using aminoacetals. In: Heterocycles. Volume 25, 1987, pp. 601-616.
  • KM Lambert, SA Aldirany, James M. Bobbitt, WF Bailey: Catalytic Metal-free Oxidation of Primary Amines to Nitriles. In: Org. Syn. Volume 96, 2018, pp. 60–79.

Awards

  • 1969: Tour Speaker of The Year Award, American Chemical Society, Southcentral
  • 1962, 1963, 1967, 1969, 1975-1982: American Chemical Society Tour Speaker
  • 1992: UCONN Alumni Teaching Award

See also

Web links

Individual evidence

  1. ↑ a b c d e Nicholas E. Leadbeater, James M. Bobbitt: TEMPO-Derived Oxoammonium Salts as Versatile Oxidizing Agents , Aldrichimica Acta 47 (2014), pp. 65-74.
  2. ^ Zerong Wang: Comprehensive Organic Name Reactions and Reagents . John Wiley & Sons, Inc., Hoboken, NJ, USA 2010, ISBN 978-0-470-63885-9 , doi : 10.1002 / 9780470638859 ( wiley.com ).
personal data
SURNAME Bobbitt, James M.
ALTERNATIVE NAMES Bobbitt, James
BRIEF DESCRIPTION American chemist
DATE OF BIRTH January 18, 1930
PLACE OF BIRTH Charleston , West Virginia