Jean Pieters

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Jean Pieters (2008)

Jean Pieters (born January 5, 1962 in Heerlen ) is a Dutch biochemist at the Biozentrum of the University of Basel , Switzerland .

Life

Jean Pieters studied biochemistry and microbiology at the University of Leuven , Belgium. After completing his doctorate at Maastricht University in the Netherlands, he went to the European Molecular Biology Laboratory (EMBL) in Heidelberg as a postdoctoral fellow in 1989 . Between 1992 and 1995 Jean Pieters did research at the Netherlands Cancer Institute in Amsterdam as a junior group leader. In 1996 he was appointed to the Institute for Immunology at the University of Basel , and in 2002 he was appointed to the Biozentrum of the University of Basel, where he has been researching and teaching as Professor of Biochemistry ever since.

Act

Pieters is studying the role of coronin proteins in activating cellular signaling . Coronin proteins are widespread in the realm of the eukaryotes and are conserved in living things, from yeast to humans. One of the most highly conserved members of this protein family, mammalian coronin 1. Jean Pieters' research team discovered that this protein is responsible for the intracellular survival of pathogenic mycobacteria. Further research by his laboratory has shown that coronin proteins regulate a wide range of physiological processes, including T-cell homeostasis, learning, memory and development. His latest work also indicates that mutations in coronin proteins could lead to immune and cognitive disorders in humans. Coronin proteins appear to be involved in important physiological metabolic processes.

Awards

  • Elected member of the Royal Netherlands Academy of Arts and Sciences in 2011
  • 2002 Friedrich Miescher Prize
  • 2001 Pfizer Research Prize
  • 1999 Eppendorf Young Investigator Award

Publications (selection)

Complete list of publications

  • Jayachandran R., Liu X., BoseDasgupta S., Mueller P. et al. (2014) Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP / Protein kinase A Signaling. PLOS Biology, 12, e1001820; PMID 24667537
  • Mueller, P., Massner, J., Jayachandran, R., et al. (2008). Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering. Nat Immunol 9, 424-431; PMID 18345003
  • Jayachandran R., Sundaramurthy V., et al. (2007). Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin. Cell 130: 37-50; PMID 17632055
  • Ferrari, G., Langen, H., M. Naito and Pieters, J. (1999). A phagosomal coat protein involved in the intracellular survival of mycobacteria. Cell, 97, 435-447. PMID 10338208
  • Tulp A, Verwoerd D, Dobberstein B, Ploegh HL, Pieters J. 1994. Isolation and characterization of the intracellular MHC class II compartment. Nature 369: 120-6 (full article). PMID 8177317

Web links

Individual evidence

  1. ↑ Curriculum Vitae. Biozentrum.unibas.ch, accessed on September 23, 2014
  2. ↑ Elected corresponding member of the Royal Dutch Academy of Sciences. knaw.nl, accessed on September 22, 2014.
  3. ↑ The winners of the Friedrich Miescher Prize ( Memento of the original from October 29, 2013 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. swissbiochem.ch, accessed on September 22, 2014. @1@ 2Template: Webachiv / IABot / www.swissbiochem.ch
  4. ↑ Pfizer Research Prize, Prize Winner 2001 ( Memento from January 30, 2010 in the Internet Archive ) pfizerforschungspreis.ch, accessed on September 22, 2014.
  5. ^ Eppendorf Award for Young European Investigators, Past Award Winners eppendorf.com, accessed on September 22, 2014.
  6. ↑ Complete list of publications Biozentrum.unibas.ch, accessed on September 22, 2014.
personal data
SURNAME Pieters, Jean
BRIEF DESCRIPTION Dutch biochemist
DATE OF BIRTH 5th January 1962
PLACE OF BIRTH Heerlen