Julius Tröger (chemist)

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The two enantiomers of Tröger's base: (5 S , 11 S ) form (top) and (5 R , 11 R ) form (bottom).

Julius Tröger (born October 10, 1862 in Leipzig , † July 29, 1942 in Braunschweig ) was a German chemist and professor.

Live and act

Tröger was born in Leipzig and studied at the University of Leipzig between 1882 and 1888. He established a connection through the reaction of p -toluidine and formaldehyde , which was given the systematic name (±) -2,8-dimethyl-6 H , 12 H -5,11-methanodibenzo [ b , f ] [1,5] diazocine, but is better known under the name Trögersche Base . Tröger was unable to explain the structure and therefore only received a grade of 3 for his doctoral thesis from the head of the department Johannes Wislicenus in 1887 . It was another 48 years before the structure could be clarified.

The structure of Tröger's base contains two conformationally hindered nitrogen atoms , which no longer allow the normally occurring Walden's reversal (inversion) and thus lead to the nitrogen atoms being the chiral centers of the molecule in this case . The separation of the enantiomers by chromatography on a chiral stationary phase was carried out in 1944 by Vladimir Prelog . The process used there established itself as a separation process for enantiomers.

In 1888 he moved to the University of Braunschweig , where he stayed until his retirement in 1928. Tröger died in Braunschweig in 1942.

literature

  • Lothar Beyer: From PhD student to important chemist: PhD in Leipzig, well-known as a chemist; Clemens Winkler: Germanium, Constantin Fahlberg: Saccharin, Theodor Curtius: Curtius'scher acid degradation, Julius Tröger: Tröger'sche Base, Paul Walden: Walden'sche reversal, Hans Bucherer: Bucherer reaction, Alwin Mittasch: Mittasch catalysts. Passage-Verlag, Leipzig 2005, ISBN 3-932-90098-7 .

Web links

Individual evidence

  1. ^ Ernest L. Eliel, Samuel H. Wilen: Stereochemistry of Organic Compounds , John Wiley & Sons, 1994, p. 360, ISBN 0-471-05446-1 .
  2. ^ Julius Tröger (1899 to 1928 as associate professor); on tu-braunschweig.de
personal data
SURNAME Tröger, Julius
BRIEF DESCRIPTION German chemist
DATE OF BIRTH October 10, 1862
PLACE OF BIRTH Leipzig
DATE OF DEATH July 29, 1942
Place of death Braunschweig