K. Frank Austen

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Karl Frank Austen (born March 14, 1928 in Akron , Ohio ) is an American immunologist .

Life

K. Frank Austen's father, Karl Arnstein , emigrated from Czechoslovakia to the United States in 1924 to work as an aerospace engineer for the Good Year Zeppelin Corporation .

Before Austen could begin studying at Amherst College , he contracted polio in 1946 . While convalescing , he took physics and chemistry at the University of Akron . He earned a bachelor's degree from Amherst College in Amherst , Massachusetts in 1951 and an MD from Harvard Medical School in Boston , Massachusetts in 1955 with a medical degree. Initially, Austen worked as an assistant doctor at Massachusetts General Hospital(MGH) also in Boston, where he was responsible for polio patients, among other things, but then went to the US Army in Fort Sam Houston in San Antonio , Texas and to the Walter Reed Military Hospital in Washington, DC for two years

In 1959 Austen became senior resident at the MGH. A research stay led him to John Humphrey and Walter Brocklehurst at the Medical Research Council in Mill Hill , London , before he took over the management of pulmonology at MGH. In 1966 Austen became chief physician for internal medicine at the Robert Breck Brigham Hospital in Boston and played a leading role in its merger with two other Boston hospitals to form Brigham and Women's Hospital .

Austen married Joyce Chapman in 1959.

Act

Austen was able to contribute significantly to the understanding of the mechanisms that trigger, amplify and control the inflammatory response . He is considered a pioneer in the biochemistry of the release of mediators from mast cells and the biological properties of leukotrienes .

In addition to the molecular biology and cell biology of the mast cell, his laboratory deals with the metabolic pathways from arachidonic acid to cysteinyl lecotrienes and prostanoids and the cytokine regulation of these substances in allergic inflammation.

Austen published more than 500 scientific publications . More than 90 of his students became university professors or heads of research institutions.

Awards (selection)

Fonts (selection)

  • ed. with Elmer L. Becker: Biochemistry of the acute allergic reactions. A symposium organized by the Council for International Organizations of Medical Sciences (established under the joint auspices of UNESCO & WHO). Philadelphia: FA Davis, 1968.
  • Contribution in: Kimishige Ishizaka (Ed.): Mast cell activation and mediator release. Basel: Karger, 1984.

Web links

Individual evidence

  1. ^ Profile of Karl Frank Austen
  2. ↑ a b K. Frank Austen MD at the Gairdner Foundation (gairdner.org); Retrieved July 20, 2013
  3. ^ A. Berry Kay: Allergy and Hypersensitivity - History and Concepts. In: A. Barry Kay, Allen P. Kaplan, Jean Bousquet, Patrick G. Holt: Allergy and Allergic Diseases. John Wiley & Sons, 2009 ISBN 978-1-4443-0092-5 p. 10 limited preview in the Google book search
  4. ↑ Book of Members 1780 – present (PDF, 524 kB) at the American Academy of Arts and Sciences (amacad.org); Retrieved July 20, 2013
  5. ^ K. Frank Austen at the National Academy of Sciences (nasonline.org); Retrieved July 20, 2013
  6. ↑ Honorary Degree Recipients by Date Received at Amherst College (amherst.edu); Retrieved July 20, 2013
  7. ^ JM Drazen: Presentation of the 2004 Kober Medal to K. Frank Austen. In: The Journal of clinical investigation. Volume 114, Number 8, October 2004, pp. 1174-1176, ISSN  0021-9738 . doi: 10.1172 / JCI23464 . PMID 15489966 . PMC 522280 (free full text).
personal data
SURNAME Austen, K. Frank
ALTERNATIVE NAMES Austen, Karl Frank (full name)
BRIEF DESCRIPTION American immunologist
DATE OF BIRTH March 14, 1928
PLACE OF BIRTH Akron , Ohio