Yoshito Kishi

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Yoshito Kishi (2002/03)

Yoshito Kishi (born April 13, 1937 in Nagoya , Japan ) is a former Morris Loeb Professor of Chemistry at Harvard University . He is known for his work in the field of organic synthesis and the total synthesis of natural products .

Kishi studied chemistry at Nagoya University , where he also received his BS and Ph.D. acquired, as well as held an assistant professorship. This was followed by a postdoc at Harvard University with Robert B. Woodward . In 1974 he became a professor of chemistry at Harvard University; a position he held until his retirement in 2009. In 1985 he was accepted into the American Academy of Arts and Sciences .

Kishi's research interests are the synthesis of complex natural products. In his working group, syntheses of palytoxin , mycoactones, halichondrins, saxitoxin and tetrodotoxin were developed.

He received special attention for the synthesis of palytoxin , which is considered one of the greatest achievements in chemical synthesis due to the complexity of the molecule with its 64 stereogenic centers . Kishi developed the new organometallic coupling reaction, the Nozaki-Hiyama-Kishi reaction , introduced by Hitoshi Nozaki and Tamejiro Hiyama , with these being ready for use. Kishi wanted to use the reaction in the synthesis of palytoxin, but it was unreliable because it depended heavily on the type of chromium preparations used. After all, Kishi was able to attribute this to the fact that small amounts of nickel were necessary (pure chromium preparations therefore achieved poor results). In 1979 he succeeded in the first total synthesis of monensin .

In 2001 he received the Tetrahedron Prize , and in 2018 the Ryōji Noyori Prize .

Web links

Individual evidence

  1. ↑ Yoshito Kishi, Robert R. Rando: Structural Basis of Protein Kinase C Activation by Tumor Promoters . In: Accounts of Chemical Research . 31, No. 4, 1998, p. 163. doi : 10.1021 / ar9600751 .
  2. ↑ 岸 義 人 . In: デ ジ タ ル 版 日本人 名 大 辞典 + Plus at kotobank.jp. Retrieved July 18, 2012 (Japanese).
  3. ↑ H. Tanino, T. Nakata, T. Kaneko, Y. Kishi: A stereospecific total synthesis of dl-saxitoxin. In: Journal of the American Chemical Society. 99, 1977, p. 2818, doi : 10.1021 / ja00450a079 .
  4. ↑ synarchive.com: Synthesis of Saxitoxin , accessed on August 16, 2017.
  5. ↑ Tomáš Hudlický, Josephine W. Reed: The way of synthesis: evolution of design and methods for natural products. Wiley, 2007, ISBN 978-3-527-32077-6 . Pp. 891-905.
  6. ↑ MC White, Nozaki-Hiyama Reaction / Nozaki-Hiyama-Kishi Reaction (pdf), Harvard, handout for course Chem 253, October 2004
  7. ↑ Kishi, J. Am. Chem. Soc., Vol. 108, 1986, p. 5644
personal data
SURNAME Kishi, Yoshito
ALTERNATIVE NAMES 岸 義 人 (Japanese)
BRIEF DESCRIPTION Japanese chemist
DATE OF BIRTH April 13, 1937
PLACE OF BIRTH Nagoya , Japan