Complement receptor 1
| Complement receptor type 1 | ||
|---|---|---|
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| according to PDB 1GKG | ||
| other names |
C3b / C4b receptor, CD antigen CD35 |
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| Properties of human protein | ||
| Mass / length primary structure | 2,039 amino acids , 223,663 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 1378 | |
| Ensemble | ENSG00000203710 | |
| UniProt | P17927 | |
| Refseq (mRNA) | NM_000573.3 | |
| Refseq (protein) | NP_000564.2 | |
| PubMed search |
1378
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The complement receptor 1 (synonymous CD35 ) is a surface protein from the complement system .
properties
The complement receptor 1 binds immune complexes with bound complement C3b or C4b and is thus involved in the innate immune response . Furthermore, it is the receptor for the cell entry of the Epstein-Barr virus . The complement receptor 1 is formed by erythrocytes , leukocytes , podocytes and follicular dendritic cells of the spleen. It is glycosylated and contains a pyrrolidone carboxylic acid .
Web links
Individual evidence
- ↑ M. Alcorlo, A. López-Perrote, S. Delgado, H. Yébenes, M. Subías, C. Rodríguez-Gallego, S. Rodríguez de Córdoba, O. Llorca: Structural insights on complement activation. In: The FEBS journal. Volume 282, Number 20, October 2015, pp. 3883-3891, doi : 10.1111 / febs.13399 , PMID 26250513 .
- ^ A. Sörman, L. Zhang, Z. Ding, B. Heyman: How antibodies use complement to regulate antibody responses. In: Molecular immunology. Volume 61, number 2, October 2014, pp. 79-88, doi : 10.1016 / j.molimm.2014.06.010 , PMID 25001046 .