Konrad Reinhart

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Konrad Anton Reinhart (born October 26, 1947 in Bamberg ) is a German anesthetist and intensive care doctor . From 1993 to 2016 he was Director of the Clinic for Anaesthesiology and Intensive Therapy at the University Hospital of the Friedrich Schiller University in Jena . Now he is Senior Professor at the Jena University Hospital, BIH Visiting Professor at the Charité Foundation and Senior Professor at the Charité University Medicine, Berlin. Reinhart is a member of the National Academy of Sciences Leopoldina , founding president of the German Sepsis Society and the Global Sepsis Alliance.

Career

Konrad Reinhart studied from 1969 to 1972 at the Ludwig Maximilians University (LMU) in Munich and from 1972 to 1975 at the Free University of Berlin human medicine . After working as a medical assistant in departments for internal medicine, neurology and surgery, he was an assistant surgeon at the Evangelical Forest Hospital in Berlin from 1976 to 1977 and in the urology department of the Franziskus Hospital in Berlin from 1977 to 1978. From 1978 to 1982 he completed further training as a specialist in anesthesiology at the Clinic for Anesthesiology and Operative Intensive Care Medicine at the Free University of Berlin with Klaus Eyrich.

In 1978 Reinhart received his doctorate from the Free University of Berlin and qualified as a professor in 1984 in anesthesiology. From 1982 to 1985 he was senior physician at the Clinic for Anaesthesiology and Intensive Care Medicine at the Free University of Berlin and there from 1985 to 1987 senior physician in charge of the operative intensive care unit at the Steglitz Clinic. From 1988 to 1989 he was Visitung Associate Professor in the Department of Physiology and Biophysics at the University of Alabama at Birmingham, USA. In 1989 he was appointed adjunct professor at the Free University of Berlin. In 1993 he was appointed C3 professor and then appointed to the chair for anesthesiology and intensive therapy at the University Clinic of the Friedrich Schiller University Jena, where he became director of the local clinic for anesthesiology and intensive therapy.

Research and activities

With over 68,000 citations and an H index of 109, Reinhart is one of the world's most cited sepsis researchers. Research focuses on epidemiology, diagnosis and treatment of sepsis. As the initiator of the German Sepsis Society (2001), the Competence Network SepNet (2001), the Center for Sepsis Control and Care (2008), the Sepsis Foundation (2012), the German Sepsis Quality Alliance (2012) and a memorandum for a national Sepsisplan, Reinhart has made a significant contribution to increasing awareness in Germany of the previously underestimated medical and health economic importance of sepsis. As a co-initiator of the Global Sepsis Alliance (2010), initiator for the 1st World Sepsis Day and a World Sepsis Declaration 2012 as well as the 1st World Sepsis Congress 2016, Reinhart played a key role in ensuring that the World Health Assembly passed the resolution “Improving the prevention, diagnosis and clinical management of sepsis ". The WHO has thus given sepsis a high priority on a global level.

Memberships and offices

  • Member of the National Academy of Sciences Leopoldina (since 08/2011)
  • Chairman of the Global Sepsis Alliance (GSA) (since 10/2010)
  • Chairman of the Sepsis Foundation (since 10/2012)
  • Chairman of the International Sepsis Forum (ISF) (2008–2010)
  • Chairman of the Sepsis and Inflammation Section of the European Society of Intensive Care Medicine (ESICM) (2006–2008)
  • Member of the Council of the World Federation of Societies of Intensive and Critical Care Medicine (WFSICCM) (since 2005–2015)
  • Member of the Advisory Board of the International Surviving Sepsis Campaign (SSC) (2004–2008)
  • Member of the management committee for the international sepsis register PROGRESS (Promoting Global Research Excellence in Severe Sepsis) (2004–2008)
  • President of the German Sepsis Society V. (2001-2009)
  • Member of the advisory board of the German Society for Anaesthesiology and Intensive Therapy (2001–2008)

Awards

  • 2016 honorary membership of the European Society of Intensive Care Medicine
  • 2016 honorary membership of the Royal Society of Physicians Thailand
  • 2015 Lohfert Prize for the sepsis project "MEDUSA"
  • 2008 Research Prize of the Free State of Thuringia
  • 1986 Carl Ludwig Schleich Prize for Habilitation

Publications

  • with C. Fleischmann-Struzek, A. Mikolajetz, D. Schwarzkopf, J. Cohen, CS Hartog, M. Pletz, P. Gastmeier and K. Reinhart: Challenges in Assessing the Burden of Sepsis and Understanding the Inequalities of Sepsis Outcomes between National Health Systems - Secular Trends in Sepsis and Infection Incidence and Mortality. In: Germany Intensive Care Med. Volume 44, No. 11, 2018, pp. 1826–1835.
  • with Carolin Fleischmann-Struzek, David M Goldfarb, Peter Schlattmann, Luregn J Schlapbach and Niranjan Kissoon: The global burden of pediatric and neonatal sepsis: a systematic review. In: Lancet Respir Med. Volume 6, 2018, pp. 223-230.
  • with R. Daniels, N. Kissoon, FR Machado, RD Schachter and S. Finfer: Recognizing Sepsis as a Global Health Priority - A WHO Resolution. In: N Engl J Med. Volume 377, No. 5, Aug 3, 2017, pp. 414-417.
  • with RS Hotchkiss, LL Moldawer, IR Turnbull and JL Vincent: Sepsis and Septic Shock. In: Nat Rev Dis Primers. Volume 2, Jun 30, 2016, p. 16045. doi: 10.1038 / nrdp.2016.45 Review
  • with F. Bloos, E. Trips, A. Nierhaus, J. Briegel, DK Heyland, U. Jaschinski, O. Moerer, A. Weyland, G. Marx, M. Gründling, S. Kluge, I. Kaufmann, K. Ott, M. Quintel, F. Jelschen, P. Meybohm, S. Rademacher, A. Meier-Hellmann, S. Utzolino, UX Kaisers, C. Putensen, G. Elke, M. Ragaller, H. Gerlach, K. Ludewig , M. Kiehntopf, H. Bogatsch, C. Engel, FM Brunkhorst and M. Loeffler; for SepNet Critical Care Trials Group. In: JAMA Intern Med. Volume 176, No. 9, Sep 1, 2016, pp. 1266–1276.
  • with K. Schmidt, S. Worrack, M. Von Korff, D. Davydow, F. Brunkhorst, U. Ehlert, C. Pausch, J. Mehlhorn, N. Schneider, A. Scherag, A. Freytag, M. Wensing and J. Gensichen; SMOOTH Study Group: Effect of a Primary Care Management Intervention on Mental Health-Related Quality of Life Among Survivors of Sepsis: A Randomized Clinical Trial. Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial. In: JAMA. Volume 315, No. 24, Jun 28, 2016, pp. 2703-2711.
  • with D. Keh, E. Trips, G. Marx, SP Wirtz, E. Abduljawwad, S. Bercker, H. Bogatsch, J. Briegel, C. Engel, H. Gerlach, A. Goldmann, SO Kuhn, L. Hüter , A. Meier-Hellmann, A. Nierhaus, S. Kluge, J. Lehmke, M. Loeffler, M. Oppert, K. Resener, D. Schädler, T. Schuerholz, P. Simon, N. Weiler, A. Weyland FM Brunkhorst and SepNet-Critical Care Trials Group: Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis: The HYPRESS Randomized Clinical Trial. In: JAMA. Volume 316, No. 17, Nov 1, 2016, pp. 1775-1785.
  • with CS Hartog, C. Natanson, J. Sun and HG Klein: EMA decision on hydroxyethyl starch solutions: a cause for concern? In: BMJ. 2014.
  • with K. Reinhart, M. Bauer, NC Riedemann and CS Hartog: New approaches to sepsis: molecular diagnostics and biomarkers. In: Clin Microbiol Rev. Volume 25, No. 4, Oct 2012, pp. 609-634.
  • with FM Brunkhorst, M. Oppert, G. Marx, F. Bloos, K. Ludewig, C. Putensen, A. Nierhaus, U. Jaschinski, A. Meier-Hellmann, A. Weyland, M. Gründling, O. Moerer, R. Riessen, A. Seibel, M. Ragaller, MW Büchler, S. John, F. Bach, C. Spies, L. Reill, H. Fritz, M. Kiehntopf, E. Kuhnt, H. Bogatsch, C. Engel , M. Loeffler, MH Kollef and T. Welte; German Study Group Competence Network Sepsis (SepNet): Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial. In: JAMA. Volume 307, No. 22, Jun 13, 2012, pp. 2390-9.
  • with FM Brunkhorst, C. Engel, F. Bloos, Andreas Meier-Hellmann, M. Ragaller, N. Weiler, O. Moerer, M. Gruendling, M. Oppert, S. Grond, D. Olthoff, U. Jaschinski, S John, R. Rossaint, T. Welte, M. Schaefer, P. Kern, E. Kuhnt, M. Kiehntopf, C. Hartog, C. Natanson and M. Loeffler for the German Competence Network Sepsis (SepNet): A Trial of Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis . In: New England Journal of Medicine . Volume 358, No. 2, Jan 10, 2008, pp. 125-139; JCR: 51.3
  • with CL Sprung, D. Annane, D. Keh, R. Moreno, M. Singer, K. Freivogel, YG Weiss, J. Benbe-nishty, A. Kalenka, H. Forst, P. Laterre, BH Cuthbertson, D. Payen and J. Briegel for the Corticus Study Group: The CORTICUS randomized, double-blind, placebo-controlled study of hydrocortisone therapy in patients with septic shock . In: New England Journal of Medicine . Volume 358, No. 2, Jan 10, 2008, pp. 111-124; JCR: 51.3
  • with F. Brunkhorst and H. Bone et al: Diagnosis and therapy of sepsis. Guidelines of the German Sepsis Society and the German Interdisciplinary Society for Intensive and Emergency Medicine. In: Internist. (Berl). Volume 47, No. 4, Apr 2006, pp. 356, 358-360, 362-368; JCR: 0.3
  • with T. Gluck, J. Luchtenberg, K. Tschaikowsky, A. Bruining, J. Bakker, S. Opal, LL Moldawer, T. Axtelle, T. Turner, S. Souza and J. Pribble: CD14 receptor occupancy in severe sepsis : Results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14). In: Crit Care Med. Volume 32, No. 5, 2004, pp. 1100-1108; JCR: 6.6
  • with JC Marshall, JL Vincent, MP Fink, DJ Cook, G. Rubenfeld, D. Foster, CJ Fisher Jr and E. Faist: Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26, 2000. In: Crit Care Med. Volume 31, No. 5, May 2003, pp. 1560-1567; JCR: 6.6
  • with E. Abraham, S. Opal, I. Demeyer, C. Doig, A. Lopezrodriguez, R. Beale, S. Svoboda, PF Laterre, S. Simon, B. Light, H. Spapen, J. Stone, A. Seibert, C. Peckelsen, C. De Deyne, R. Postier, V. Pettilä, C. Sprung, A. Artigas, SA Percell, V. Shu, C. Zwingelstein, J. Tobias, L. Poole, JC Stolzenbach and AA Creasey for Trial Study Group: Efficacy and Safety of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor) in Severe Sepsis. In: JAMA. Volume 290, No. 9, 2003, pp. 238-255; JCR: 23.2
  • with Andreas Meier-Hellmann, R. Beale, H. Forst, D. Boehm, S. Willatts, KF Rothe, M. Adolph, JE Hoffmann, M. Boehme and DL Bredle: Open randomized phase II trial of an ex-tracorporeal endotoxin adsorber in suspected gram-negative sepsis. In: Crit Care Med. Volume 32, No. 8, 2004, pp. 1662-1668; JCR: 6.6
  • with T. Menges, B. Gardlund, JH Zwaveling, M. Smithes, JL Vincent, JM Tellado, A. Salgado-Remigio, R. Zimlichman, S. Withington, K. Tschaikowsky, R. Brase, P. Damas, H. Kupper, J. Kempeni, J. Eiselstein, M. Kaul and The AFELIMOMAB Sepsis Study Group: Randomized placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES study. In: Crit Care Med. Volume 29, 2001, pp. 765-769; JCR: 6.6
  • with E. Abraham, P. Svoboda, A. Seibert, D. Olthoff, A. Dalnogare, R. Postier, G. Hempelmann, T. Butler, E. Martin, C. Zwingelstein, S. Percell, V. Shu, A Leighton and AA Creasey: Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: a multicenter, randomized, placebo-controlled, single-blind, dose escalation study. In: Crit Care Med. Volume 29, No. 11, 2001, pp. 2081-2089; JCR: 6.6
  • with Waheedullah Karzai and Michael Meisner: Procalcitonin as a marker of the systemic inflammatory response to infection. In: Int Care Med. Volume 26, No. 9, 2000, pp. 1193-1200; JCR: 4.4
  • with Thomas Uhlig: Friedrich Schiller University Jena: Clinic for Anaesthesiology and Intensive Care Medicine. In: Jürgen Schüttler (Ed.): 50 Years of the German Society for Anaesthesiology and Intensive Care Medicine: Tradition and Innovation. Springer, Berlin / Heidelberg / New York 2003, ISBN 3-540-00057-7 , pp. 453-458.

literature

  • Konrad Reinhart, Thomas Uhlig: Friedrich Schiller University Jena: Clinic for Anaesthesiology and Intensive Care Medicine. In: Jürgen Schüttler (Ed.): 50 Years of the German Society for Anaesthesiology and Intensive Care Medicine: Tradition and Innovation. Springer, Berlin / Heidelberg / New York 2003, ISBN 3-540-00057-7 , pp. 453–458, here: pp. 455–458.

Web links

Individual evidence

  1. ^ German Sepsis Society - foundation . Retrieved December 19, 2011.
  2. ↑ Clinic for Anaesthesiology and Intensive Therapy, University Hospital of Friedrich Schiller University Jena ( Memento from October 11, 2014 in the Internet Archive ). Retrieved November 25, 2011.
  3. ^ Google Scholar. Retrieved October 18, 2019 .
  4. ↑ Memorandum for a National sepsis plan. (PDF) Sepsis Foundation, accessed on November 7, 2019 .
  5. ^ World Sepsis Declaration. Retrieved October 18, 2019 .
  6. ^ World Sepsis Congress. Retrieved October 18, 2019 .
  7. ↑ WHA resolution. (PDF) Retrieved October 18, 2019 .
  8. ↑ K. Reinhart, R. Daniels, N. Kissoon, FR Machado, RD Schachter, S. Finfer: Recognizing Sepsis as a Global Health Priority - A WHO Resolution . In: N Engl J Med. August 2017, doi : 10.1056 / NEJMp1707170 .
  9. ↑ Member entry of Konrad Reinhart (with picture) at the German Academy of Natural Scientists Leopoldina , accessed on July 19, 2016.
  10. ↑ Global Sepsis Alliance - About ( Memento from March 12, 2016 in the Internet Archive ). Retrieved December 19, 2011.
  11. ↑ Lohfert Prize 2015. (PDF) Retrieved October 18, 2019 .
personal data
SURNAME Reinhart, Konrad
ALTERNATIVE NAMES Reinhart, Konrad Anton (full name)
BRIEF DESCRIPTION German anesthetist and intensive care physician
DATE OF BIRTH October 26, 1947
PLACE OF BIRTH Bamberg