Kurtoxin

Kurtoxin
	Existing structure data : PDB 1T1T
Mass / length primary structure	63 amino acids , 7,394 Da
Identifier
External IDs	UniProt : P58910 ;

Kurtoxin is a neurotoxin from the South African thick-tailed scorpion Parabuthus transvaalicus .

properties

Kurtoxin is a peptide and a scorpion toxin in the venom of the South African thick-tailed scorpion . In addition, the toxins bestoxin , birtoxin , dortoxin and altitoxin are also present in the poison . Kurtoxin has four disulfide bridges . Kurtoxin binds to binding site 3 of voltage-gated sodium channels ( Nav1.2 / SCN2A ) and calcium channels ( Cav3.2 / CACNA1H T-type ) in mammals and inhibits the inactivation of sodium channels. Furthermore, it binds to calcium channels of the P, N and L types, but not to Cav1.2 / CACNA1C , Cav2.1 / CACNA1A , Cav2.2 / CACNA1B and Cav2.3 / CACNA1E .

Web links

MeSH kurtoxin

Individual evidence

↑ SS Sidach, IM Mintz: Kurtoxin, a gating modifier of neuronal high- and low-threshold ca channels. In: The Journal of neuroscience: the official journal of the Society for Neuroscience. Volume 22, Number 6, March 2002, pp. 2023-2034, PMID 11896142 .
Jump up ↑ B. Inceoglu, J. Lango, I. Pessah, B. Hammock: Three structurally related, highly potent, peptides from the venom of possess divergent biological activity . In: Toxicon . 45, No. 6, 2005, ISSN 0041-0101 , pp. 727-733. doi : 10.1016 / j.toxicon.2005.01.020 . PMID 15804521 .
↑ CW Lee, C. Bae, J. Lee, JH Ryu, HH Kim, T. Kohno, KJ Swartz, JI Kim: Solution structure of kurtoxin: a gating modifier selective for Cav3 voltage-gated Ca (2+) channels. In: Biochemistry. Volume 51, number 9, March 2012, pp. 1862–1873, doi : 10.1021 / bi201633j , PMID 22329781 , PMC 3295331 (free full text).
↑ RS Chuang, H. Jaffe, L. Cribbs, E. Perez-Reyes, KJ Swartz: Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin. In: Nature Neuroscience . Volume 1, Number 8, December 1998, pp. 668-674, doi : 10.1038 / 3669 , PMID 10196582 .

[1] SS Sidach, IM Mintz: Kurtoxin, a gating modifier of neuronal high- and low-threshold ca channels. In: The Journal of neuroscience: the official journal of the Society for Neuroscience. Volume 22, Number 6, March 2002, pp. 2023-2034, PMID 11896142 .

[pmid15804521-2] Jump up ↑ B. Inceoglu, J. Lango, I. Pessah, B. Hammock: Three structurally related, highly potent, peptides from the venom of possess divergent biological activity . In: Toxicon . 45, No. 6, 2005, ISSN 0041-0101 , pp. 727-733. doi : 10.1016 / j.toxicon.2005.01.020 . PMID 15804521 .

[3] CW Lee, C. Bae, J. Lee, JH Ryu, HH Kim, T. Kohno, KJ Swartz, JI Kim: Solution structure of kurtoxin: a gating modifier selective for Cav3 voltage-gated Ca (2+) channels. In: Biochemistry. Volume 51, number 9, March 2012, pp. 1862–1873, doi : 10.1021 / bi201633j , PMID 22329781 , PMC 3295331 (free full text).

[4] RS Chuang, H. Jaffe, L. Cribbs, E. Perez-Reyes, KJ Swartz: Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin. In: Nature Neuroscience . Volume 1, Number 8, December 1998, pp. 668-674, doi : 10.1038 / 3669 , PMID 10196582 .