Solubilizer

In chemistry and pharmacy, a solubilizer is the name given to a substance which, through its presence, contributes to the solution of poorly soluble substances in a solvent . Solubilizers are required in the pharmaceutical industry , for example , to produce injection solutions or to make hormones and vitamins water-soluble.

There are three different ways of functioning:

1. The complex formation (substance and solubilizer combine to form a complex and together have better solubility. Examples: sodium benzoate , sodium salicylate )
2. The change in the dissolving power of the solvent (substances that change the solvent properties , such as disrupting the cluster structure of water. Examples: Structure breakers for water include glycerol, macrogols)
3. Absorption of the substance to be dissolved in surfactant micelles (absorption of substances into the inside of the micelle. Examples: lecithin , glycocholate)

literature

Bauer, Frömming, Führer: Textbook of Pharmaceutical Technology , Wissenschaftliche Verlagsgesellschaft, Stuttgart, 2006. ISBN 3-804-72222-9