Sodium salicylate

Structural formula
General
Surname	Sodium salicylate
other names	Salicylic acid sodium salt 2-hydroxybenzoic acid sodium salt SODIUM SALICYLATE ( INCI )
Molecular formula	C 7 H 5 NaO 3
Brief description	white, odorless solid
External identifiers / databases
CAS number 54-21-7 EC number 200-198-0 ECHA InfoCard 100,000.181 PubChem 16760658 ChemSpider 5689 DrugBank DB01398 Wikidata Q414547
properties
Molar mass	160.11 g mol −1
Physical state	firmly
density	1.561 g cm −3
Melting point	200  ° C
solubility	very light in water (1000 g l −1 at 20 ° C)
safety instructions
GHS labeling of hazardous substances Caution H and P phrases H: 302-319 P: 305 + 351 + 338
Toxicological data	930 mg kg −1 ( LD 50 ,  rat ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Sodium salicylate is the sodium salt of salicylic acid . Sodium salicylate serves as a precursor to the synthesis of acetylsalicylic acid (ASA).

Extraction and presentation

Sodium salicylate is obtained by saturating sodium phenolate with carbon dioxide under high pressure and elevated temperature. This is the Kolbe-Schmitt reaction , which was introduced industrially in 1844 .

use

Sodium salicylate is used:

• as an anti-inflammatory and anti- pyretic (similar properties to salicylic acid , but better tolerated, but less well tolerated than ASA)
• as a keratolytic for topical use. In the past also used to sclerose varicose veins
• as detection means for nitrate ions (formation of yellow colored sodium nitrosalicylate ).
• as a preservative in the food and cosmetics industries
• as a propellant charge in whistling fireworks
• as a gloss additive for cyanidic brass electrolytes
• as a scintillator substance in luminescence spectroscopy
• as denaturant in cosmetics

Individual evidence

1. ↑ Entry on SODIUM SALICYLATE in the CosIng database of the EU Commission, accessed on December 28, 2019.
2. ↑ ^{a b} Data sheet sodium salicylate (PDF) from Merck , accessed on January 19, 2011.
3. ^ ET Spielberg, PS Campbell, KC Szeto, B. Mallick, J. Schaumann, A.-V. Mudring: Sodium Salicylate: An In ‐ Depth Thermal and Photophysical Study . In: Chem. Eur. J. Band 24 , no. 58 , 2018, p. 15638–15648 , doi : 10.1002 / chem . 201803045 .
4. ↑ ^{a b c d} Entry on sodium salicylate in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .