Lin He

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Lin He ( Chinese  何琳 , Pinyin Hé Lín ; born January 1974 in Fujian Province , China ) is a Sino-US molecular biologist. She is Associate Professor of Cell and Developmental Biology at the University of California, Berkeley , in the Faculty of Molecular and Cell Biology. There she heads a laboratory to identify non-coding DNA that could play a role in cancer development and tumor self-preservation.

biography

Lin He grew up in Beijing before the skyscraper era. Her parents were engineers. She was admitted to the Tsinghua University Biology Faculty in 1992 , where she graduated with a Bachelor of Science degree in 1997 . During her studies, she studied the relationship between pigmentation genes and behavior, as well as neuropathology. She and her fellow students identified the mouse gene mutation mahoganoid , which exhibits age-dependent neural degeneration, as can be seen in prion diseases (such as mad cow disease ), but without the degeneration-resistant misfolded proteins of prion diseases. In 2003, Lin He received her PhD from Stanford Medical School . For this she had worked with Gregory S. Barsh . Lin He was a postdoctoral fellow with Greg Hannon at the Cold Spring Harbor Laboratory from 2003 to 2007 . In 2008, Lin He went to the University of California, Berkeley .

Lin He's research focuses on the role of non-coding microRNAs in tumor development and self-preservation. She was able to prove that there is no such thing as superfluous DNA.

"We have come a long way to realize that miRNAs truly play an important role."

"It took us a long time to understand that miRNAs play a really important role."

- Lin He

In particular, she found that miR-34 , a special microRNA family, plays an important role in blocking the replication of tumor cells in lung cancer. In 2017, her research focused on understanding the mechanism of tumor suppression by miR-34. Her laboratory also examines the miR-17/92 family . family. Differential expressions of these microRNA clusters have been observed in lymphatic cancer , which could mean that members of the miR-17/92 family are potential oncogenes . His work has appeared in Nature , Nature Genetics, and Science .

Lin He lives in Northern California with her husband Kai Jiang and their son Gabriel Jiang.

Awards

  • In 2009, Lin He and the computer scientist Maneesh Agrawala received the five-year MacArthur Fellowship, each endowed with USD 500,000 .
  • In 2009 she received the TWAS Prize .

Publications

  • S. Chen, B. Lee, A. Lee, A. Modzelewski, Lin He. Highly Efficient Mouse Genome Editing by CRISPR Ribonucleoprotein Electroporation of Zygotes . J. Biol Chem May 5, 2016
  • V. Olive, E. Sabio, AC Minella, Lin He. Outside the coding genome, microRNAs make a big difference. Science Signaling , Sci Signal. 17th May 2015
  • R. Song, P. Walentek, N. Sponer, M. Lize, A. Klimke, JS Lee, GR Dixon, P. Lishko, M. Kessel, Lin He. miR-34/449 miRNAs are required for motile ciliogenesis by repressing Cp110 . Nature, research article, June 5, 2014
  • J. Y, Krzeszinski, W. Wei, H. Huynh, Z. Jin, T. Chang, X. Xie, Lin He, MS Lingegowda, G. Lopez-Berestein, AK Sood, JT Mendell, Y. Wan. MiR-34a blocks Osteoporosis and Bone Metastasis by Inhibiting Osteoclastogenesis and Tgif2 . Nature, August 28, 2014
  • B. Xue B, Lin He. An expanding universe of the non-coding genome in cancer biology . Carcinogenesis, June 2014
  • N. Okada, M. Ribeiro, A. Biton, C. Lin, G. Lai, P. Bu, H. Vogel, DM Jablons, A. Keller, JE Wilkinson, B. He, TP Speed, Lin He. A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes and Development, March 1, 2014
  • V. Olive, E. Sabio, M. Bennett, C. De Jong, A. Biton, JC McGann, SK Greaney, NM Sodir, AY Zhou, A. Balakrishnan, M. Foth, M. Luftig, A. Goga, TP Speed, Z. Xuan, G. Evan, Y. Wan, A. Minella, Lin He. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis . Elife. 15 October 2013
  • Y. Choi, C. Lin, Y. Zhong, X. He, S. Kim, N. Okada, P. Bu, MJ Bennett, C. Chen, A. Ozturk, G. Hicks, GJ Hannon, Lin He. miR-34a miRNA provides a barrier for somatic cell reprogramming . Nature Cell Biology, October 23, 2011
  • Lin He. Post-transcriptional regulation of PTEN dosage by non-coding RNAs . Science Signaling November 2, 2010
  • V. Olive, MJ Bennett, JC Walker, C. Ma, I. Jiang, C. Cordon-Cardo, Q. Li, SW Lowe, GJ Hannon, Lin He. miR-19 is a key oncogenic component of mir-17-92 . Genes and Development December 15, 2009
  • Lin He, X. He, SW Lowe, GJ Hannon. microRNAs join the p53 pathway, another piece of the tumor suppressor puzzle . Nat Rev Cancer. November 2007
  • Lin He, X. He, LP Lim, E. de Stanchina, Z. Xuan, Y. Liang, W. Xue, L. Zender, J. Magnus, D. Ridzon, AL Jackson, PS Linsley, C. Chen, SW Lowe, MA Cleary, GJ Hannon. A microRNA component of the p53 tumor suppressor network . Nature. June 28, 2007
  • Lin He, JM Thomson, MT Hemann, E. Hernando-Monge, D. Mu, S. Goodson, S. Powers, C. Cordon-Cardo, SW Lowe, GJ Hannon, SM Hammond. A microRNA polycistron as a potential human oncogene . Nature. June 9, 2005
  • Lin He, GJ Hannon. MicroRNAs: small RNAs with a big role in gene regulation . Nat Rev Genet. July 2004
  • Lin He, XY Lu, AF Jolly AG Eldridge, SJ Watson, PK Jackson, GS Barsh. TM Gunn. Spongiform encephalopathy caused by defects of an E3 ubiquitin ligase in mahoganoid mice . Science, January 31, 2003
  • Lin He, T. m. Gunn, DM Bouley, XY Lu, SJ Watson, SF Schlossman, JS Duke-Cohan, GS Barsh. A biochemical function for attractin in agouti-induced pigmentation and obesity . Nat Genet. January 2001
  • TM Gunn, K. A: Miller, Lin He, RW Hyman, RW Davis, A. Azarani, SF Schlossman, J. S: Duke-Cohan, GS Barsh. The mouse mahogany locus encodes a transmembrane form of human attractin . Nature March 11, 1999

Web links

  • Lin He. Official website at the University of California Berkeley. In: mcb.berkeley.edu.

Individual evidence

  1. ^ Faculty Research Page. Lin He. In: mcb.berkeley.edu. Accessed November 4, 2018 .
  2. ↑ 清华 校友 何琳 获 2009 年 美国 麦克阿瑟 天才 奖. In: tsinghua.edu.cn. September 23, 2009, Retrieved November 4, 2018 (Chinese).
  3. ↑ a b Lin He - MacArthur Foundation. In: macfound.org. Accessed November 4, 2018 .
  4. ↑ L. He, C. Sedwick: Lin He: "Junk" DNA isn't. In: Journal of Cell Biology . Volume 211, number 1, October 2015, pp. 4–5, doi : 10.1083 / jcb.2111pi , PMID 26459593 , PMC 4602029 (free full text).
  5. ^ Peggy Kolm: Women in Science: 2009 MacArthur Fellows: Lin He and Beth Shapiro. In: blog.sciencewomen.com. September 29, 2009, accessed November 4, 2018 .
  6. ↑ L. He, C. Sedwick: Lin He: "Junk" DNA isn't. In: Journal of Cell Biology . Volume 211, number 1, October 2015, pp. 4–5, doi : 10.1083 / jcb.2111pi , PMID 26459593 , PMC 4602029 (free full text).
  7. ^ Robert Sanders, Sarah Yang: Two young UC Berkeley faculty members receive MacArthur "genius" award. In: berkeley.edu. September 21, 2009, accessed November 4, 2018 .
  8. ↑ Prizes & Awards. In: twas.org. Accessed November 4, 2018 .
personal data
SURNAME Hey, Lin
ALTERNATIVE NAMES 何琳 (Chinese)
BRIEF DESCRIPTION Chinese-American molecular biologist
DATE OF BIRTH January 1974
PLACE OF BIRTH Fujian Province , China