Lipoxygenases

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Lipoxygenases are enzymes that oxidize polyunsaturated fatty acids with two oxygen atoms to form eicosanoids . They therefore belong to the group of dioxygenases . Several lipoxygenases play a role in, among other arachidonic acid - metabolism of mammals and plant linoleic acid metabolism. The enzymes usually each have up to three iron ions in their active center as a cofactor . In the mushroom kingdom , lipoxygenases have also been described which have manganese in the catalytic center instead of iron. An example of such a lipoxygenase is the Mn-LOX from Gaeumannomyces graminis.

The lipoxygenases include

Individual evidence

  1. D. Führling: Lipoxygenase and linoleic acid hydroperoxide isomerase in barley (Hordeum vulgare) , Dissertation TU Berlin, Department 13 - Food Technology and Biotechnology (1975), DNB-Link: DNB, catalog of the German National Library
  2. a b Swiss Institute of Bioinformatics (SIB): PROSITE documentation PDOC00077. Lipoxygenase iron-binding catalytic domain. Retrieved August 14, 2011 .
  3. Ernst H Oliw: Plant and fungal lipoxygenases. In: Prostaglandins & Other Lipid Mediators . Volume 68-69, 2002, pp. 313-323, doi : 10.1016 / S0090-6980 (02) 00037-0 .