MAGE-C1
| MAGE-C1 | ||
|---|---|---|
| other names |
CT7.1 |
|
| Properties of human protein | ||
| Mass / length primary structure | 123,643 Da / 1,142 amino acids | |
| Identifier | ||
| Gene name | MAGEC1 | |
| External IDs | ||
| Occurrence | ||
| Homology family | HOG000113459 | |
MAGE-C1 ( English melanoma antigen C1 ), also Cancer / Testis Antigen 7 (CT7), is a human tumor antigen from the group of tumor testis antigens .
properties
MAGE-C1 is 1,142 amino acids long and has a mass of 123,643 Da . It is up to four serines phosphorylated , S63, S207, S382 and S1063. MAGE-C1 has anti- apoptotic properties. It binds to NY-ESO-1 . It is not found as a tumor antigen in healthy cells (except in immunoprivileged spermatocytes ), but is often expressed in tumors , e.g. B. multiple myeloma . There it is produced by malignant plasma cells . It is therefore a target antigen in the development of cancer vaccines and cancer immunotherapies with adoptive cell transfer .
Individual evidence
- ^ A b F. de Carvalho, AL Vettore, GW Colleoni: Cancer / Testis Antigen MAGE-C1 / CT7: new target for multiple myeloma therapy. In: Clinical & developmental immunology. Volume 2012, 2012, p. 257695, doi: 10.1155 / 2012/257695 , PMID 22481966 , PMC 3310219 (free full text).
- ↑ HJ Cho, OL Caballero, S. Gnjatic, VC Andrade, GW Colleoni, AL Vettore, HH Outtz, S. Fortunato, N. Altorki, CA Ferrera, R. Chua, AA Jungbluth, YT Chen, LJ Old, AJ Simpson: Physical interaction of two cancer-testis antigens, MAGE-C1 (CT7) and NY-ESO-1 (CT6). In: Cancer immunity. Volume 6, 2006, p. 12, PMID 17137291 .