mRNA cap methyltransferase
| MRNA-cap-methyltransferase | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 476 amino acids | |
| Isoforms | hCMT1a, hCMT1b | |
| Identifier | ||
| Gene name | RNMT | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.1.1.56 , methyltransferase | |
| Response type | Methylation | |
| Substrate | S-adenosyl-L-methionine + G (5 ') pppR RNA | |
| Products | S-adenosyl-L-homocysteine + m 7 G (5 ') pppR RNA | |
| Occurrence | ||
| Parent taxon | multicellular animals | |
The mRNA-cap-methyltransferase (MT) ( gene name: RNMT ) is the enzyme in the cell nucleus of animals that catalyzes the attachment of a 5'-cap structure to freshly synthesized mRNA . The reaction is important for the protection and further processing of the mRNA. The enzyme is part of the capping complex that forms in eukaryotes after the pre-initiation complex breaks down at the beginning of transcription . In humans, the enzyme is found in all types of tissue .
Individual evidence
- ↑ Homologues at OMA
- ↑ UniProt O43148
- ↑ Buratowski / reactome: Methylation of GMP-cap by RNA methyltransferase ( page no longer available , search in web archives ) Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.
Web links
- reactome: mRNA capping - doi : 10.3180 / REACT_1470.1