Mx1
| Mx1 | ||
|---|---|---|
| other names |
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Existing structural data : 3LJB , 3SZR , 3ZYS , 4P4S , 4P4T , 4P4U |
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| Properties of human protein | ||
| Mass / length primary structure | 75,520 daltons / 662 amino acids | |
| Isoforms | 2 | |
| Identifier | ||
| Gene names | MX1 ; IFI78, MxA, MX | |
| External IDs | ||
| Orthologue | ||
| human | House mouse | |
| Entrez | 4599 | 17858 |
| Ensemble | ENSG00000157601 | ENSMUSG00000023341 |
| UniProt | P20591 | Q61924 |
| Refseq (mRNA) | NM_001144925 | NM_013606 |
| Refseq (protein) | NP_001138397 | NP_038634 |
| Gene locus | Chr 21: 41.42 - 41.46 Mb | Chr 16: 97.69 - 97.72 Mb |
| PubMed search | 4599 |
17858
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Mx1 ( English Interferon-induced GTP-binding protein Mx1 , Interferon-induced GTP-binding protein Mx1 ', synonym MxA ) is a GTPase and a resistance factor against RNA viruses , in particular those having a genome of negative polarity as the influenza virus A .
properties
The gene expression of Mx1 is interferons induced type I and III, for example. B. during infection with influenza viruses . The Mx1 gene occurs in one to three copies in all vertebrates, with the exception of toothed whales . Presumably Mx1 binds to the ribonucleoprotein . Mx1 forms circular oligomers around liposomes .
Individual evidence
- ↑ a b c J. Verhelst, P. Hulpiau, X. Saelens: Mx proteins: antiviral gatekeepers that restrain the uninvited. In: Microbiology and molecular biology reviews: MMBR. Volume 77, number 4, December 2013, ISSN 1098-5557 , pp. 551-566, doi : 10.1128 / MMBR.00024-13 , PMID 24296571 , PMC 3973384 (free full text).
- ↑ O. Haller, P. Staeheli, M. Schwemmle, G. Kochs: Mx GTPases: dynamin-like antiviral machines of innate immunity. In: Trends in microbiology. Volume 23, number 3, March 2015, ISSN 1878-4380 , pp. 154-163, doi : 10.1016 / j.tim.2014.12.003 , PMID 25572883 .
- ↑ Benjamin A. Braun, Amir Marcovitz, J. Gray Camp, Robin Jia, Gill Bejerano: Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whales. In: Proceedings of the National Academy of Sciences. , P. 201501844, doi : 10.1073 / pnas.1501844112 .
- ↑ O. Haller, G. Kochs: Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity. In: Journal of interferon & cytokine research: the official journal of the International Society for Interferon and Cytokine Research. Volume 31, number 1, January 2011, ISSN 1557-7465 , pp. 79-87, doi : 10.1089 / jir.2010.0076 , PMID 21166595 .