Macropinosome

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A macropinosome is a cell organelle that is temporarily formed in eukaryotes during macropinocytosis .

properties

Macropinosomes are liquid-filled vesicles that are invaded by the cell membrane during macropinocytosis (a form of endocytosis ) .

An apoptosis- independent form of cell death with excessive formation of macropinosomes is called methuosis .

The Ebola virus , vaccinia virus , adenovirus , some picornaviruses and human herpesvirus 8 use Makropinosom-like vesicles for cell entry. The Shiga toxin , Salmonella and Legionella pneumophila as well as some protozoa formed by EHEC are taken up into cells via macropinosomes.

Individual evidence

  1. ↑ MC Kerr, RD Teasdale: Defining macropinocytosis. In: Traffic (Copenhagen, Denmark). Volume 10, Number 4, April 2009, pp. 364-371, doi : 10.1111 / j.1600-0854.2009.00878.x , PMID 19192253 .
  2. ↑ WA Maltese, JH Overmeyer: non-apoptotic cell death associated with perturbations of macropinocytosis. In: Frontiers in physiology. Volume 6, 2015, p. 38, doi : 10.3389 / fphys.2015.00038 , PMID 25762935 , PMC 4329815 (free full text).
  3. ↑ J. Mercer, A. Helenius: Virus entry by macropinocytosis. In: Nature cell biology. Volume 11, Number 5, May 2009, pp. 510-520, doi : 10.1038 / ncb0509-510 , PMID 19404330 .
  4. ↑ MF Saeed, AA Kolokoltsov, T. Albrecht, RA Davey: Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes. In: PLoS pathogens. Volume 6, number 9, 2010, p. E1001110, doi : 10.1371 / journal.ppat.1001110 , PMID 20862315 , PMC 2940741 (free full text).
  5. ↑ M. Valiya Veettil, S. Sadagopan, N. Kerur, S. Chakraborty, B. Chandran: Interaction of c-Cbl with myosin IIA regulates Bleb associated macropinocytosis of Kaposi's sarcoma-associated herpesvirus. In: PLoS pathogens. Volume 6, number 12, 2010, p. E1001238, doi : 10.1371 / journal.ppat.1001238 , PMID 21203488 , PMC 3009604 (free full text).
  6. ↑ MC Kerr, JT Wang, NA Castro, NA Hamilton, L. Town, DL Brown, FA Meunier, NF Brown, JL Stow, RD Teasdale: Inhibition of the PtdIns (5) kinase PIKfyve disrupts intracellular replication of Salmonella. In: The EMBO journal. Volume 29, number 8, April 2010, pp. 1331-1347, doi : 10.1038 / emboj.2010.28 , PMID 20300065 , PMC 2868569 (free full text).
  7. ↑ TM de Carvalho, ES Barrias, W. de Souza: Macropinocytosis: a pathway to protozoan infection. In: Frontiers in physiology. Volume 6, 2015, p. 106, doi : 10.3389 / fphys.2015.00106 , PMID 25914647 , PMC 4391238 (free full text).