Markus Affolter

from Wikipedia, the free encyclopedia
Markus Affolter, 2011

Markus Affolter (born June 3, 1958 in Seeberg ) is a Swiss developmental biologist and professor. He conducts research at the Biozentrum of the University of Basel .

Life

Markus Affolter studied biology at the ETH Zurich and at the Laval University in Québec . Following his doctoral thesis at Laval University, he went to the Biozentrum of the University of Basel as a postdoctoral fellow in 1988 . In Walter Gehring's laboratory , Markus Affolter began his research work with the fruit fly Drosophila melanogaster. In 2000 he became Assistant Professor and in 2005 Full Professor of Developmental Biology at the Biozentrum of the University of Basel .

Act

Markus Affolter researches the cellular and molecular processes involved in the formation of organs and blood vessel networks in the fruit fly Drosophila melanogaster and in the zebrafish . Markus Affolter succeeded in documenting the network formation in Drosophila and in the zebrafish with the help of high-resolution microscopy using live imaging examinations. This now makes it possible to better understand the function of molecules in morphogenesis . In addition, his laboratory, in collaboration with the University of Freiburg , Germany, and the University of Lausanne , Switzerland, showed that the morphogen Dpp and the Pentagone feedback controller perform key functions in proportional tissue growth (scaling) in the wing disc of the fruit fly.

Awards

Publications (selection)

Complete list of publications

  • Anna Lenard, Elin Ellertsdottir, Lukas Herwig, Alice Krudewig, Heinz-Georg Belting, Markus Affolter: In Vivo Analysis Reveals A Highly Stereotypic Morphogenetic Pathway of Vascular Anastomosis. In: Dev Cell. Volume 25, No. 5, 2013, pp. 492-506.
  • Emmanuel Caussinus, Oguz Kanca, Markus Affolter: Fluorescent fusion protein knockout mediated by anti-GFP nanobody. In: Nat Struct Mol Biol. No. 19, 2011, pp. 117-121.
  • Fisun Hamaratoglu, Aitana Morton de Lachapelle, George Pyrowolakis, Sven Bergmann, Markus Affolter: Dpp Signaling Activity Requires Pentagone to Scale with Tissue Size in the Growing Drosophila Wing Imaginal Disc. In: PLoS Biol. Volume 9, No. 10, 2011, article e1001182.
  • Lukas Herwig, Yannick Blum, Alice Krudewig, Elin Ellertsdottir, Anna Lenard, Heinz-Georg Belting, Markus Affolter: Distinct Cellular Mechanisms of Blood Vessel Fusion in the Zebrafish Embryo. In: Curr Biol. Volume 21, No. 22, 2011, pp. 1-7.
  • A. Weiss, E. Charbonnier, E. Ellertsdottir, A. Tsirigos, C. Wolf, R. Schuh, G. Pyrowolakis, M. Affolter: A conserved activation element in BMP signaling during Drosophila development. In: Nat Struct Mol Biol. Volume 17, No. 1, 2010, pp. 69-76.
  • E. Caussinus, J. Colombelli, M. Affolter: Tip-cell migration controls stalk-cell intercalation during Drosophila tracheal tube elongation. In: Curr Biol. Volume 18, No. 22, 2008, pp. 1727-1734.
  • C. Cabernard, M Affolter .: Distinct Roles for Two Receptor Tyrosine Kinases in Epithelial Branching Morphogenesis in Drosophila. In: Dev Cell. Volume 9, 2005, pp. 831-842.
  • G. Pyrowolakis, B. Hartmann, B. Müller, K. Basler, M. Affolter: A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. In: Dev Cell. Volume 7, 2004, pp. 2229-2240.
  • A. Jaźwińska, C. Ribeiro, M. Affolter: Piopio and Dumpy, two apically secreted proteins, are required for tube remodeling during tracheal morphogenesis in Drosophila. In: Nat Cell Biol. Vol. 5, 2003, pp. 895-901.
  • B. Müller, B. Hartmann, J. Pyrowolakis, M. Affolter, K. Basler: Conversion of an extracellular Dpp / BMP morphogen gradient into an inverse transcriptional gradient. In: Cell. Volume 113, 2003, pp. 221-233.
  • C. Ribeiro, A. Ebner, M. Affolter: In Vivo Imaging Reveals Different Cellular Functions for FGF and Dpp Signaling in Tracheal Branching Morphogenesis. In: Dev Cell. Volume 2, 2002, pp. 677-683.
  • T. Marty, B. Müller, K. Basler, M. Affolter: Schnurri mediates Dpp-dependent repression of brinker transcription. In: Nat Cell Biol. Vol. 5, 2000, pp. 359-369.
  • NC Grieder, D. Nellen, R. Burke, K. Basler, M. Affolter: schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1. In: Cell. Volume 81, 1995, pp. 791-800.
  • E. Ruberte, T. Marty, D. Nellen, M. Affolter, K. Basler: An absolute requirement for both the type II and type I receptors, punt and thick veins, for Dpp signaling in vivo. In: Cell. Volume 80, 1995, pp. 889-897.
  • D. Nellen, M. Affolter, K. Basler: Receptor serine / threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. In: Cell. Volume 78, 1994, pp. 225-237.

Web links

Video links

Individual evidence

  1. ↑ Curriculum Vitae
  2. ^ Research group
  3. ^ KM Hunter Award National Cancer Institutes of Canada
  4. ^ M. Affolter, T. Marty, MA Vigano, A. Jaźwińska: Nuclear interpretation of Dpp signaling in Drosophila. In: The EMBO journal. Volume 20, number 13, July 2001, pp. 3298-3305, doi : 10.1093 / emboj / 20.13.3298 , PMID 11432817 , PMC 125521 (free full text) (review).
  5. ^ Member entry by Markus Affolter at the German Academy of Sciences Leopoldina , accessed on April 12, 2015.
  6. ↑ Complete list of publications Biozentrum.unibas.ch. Retrieved June 18, 2014.
personal data
SURNAME Affolter, Markus
BRIEF DESCRIPTION Swiss developmental biologist
DATE OF BIRTH June 3, 1958
PLACE OF BIRTH Seeberg