Maurotoxin

Potassium channel toxin alpha-KTx 6.2
	according to PDB 1TXM
other names	Maurotoxin, MTX
	Existing structure data : PDB 1WPD , PDB 1WT7
Mass / length primary structure	34 amino acids , 3,621 Da
Identifier
External IDs	UniProt : P80719 ;

Maurotoxin (synonymous potassium channel toxin alpha-KTx 6.2 ) is a neurotoxin from the scorpion Scorpio palmatus .

properties

Maurotoxin is a protein and scorpion toxin . It binds and inhibits the voltage-gated potassium channels Shaker B , Kv1.2 / KCNA2 ( IC ₅₀ = 0.8 nM ), Kv1.1 / KCNA1 (IC ₅₀ = 45 nM), Kv1.3 / KCNA3 (IC ₅₀ = 180 nM) and KCa3.1 / KCNN4 (IC ₅₀ = 1 nM). It also inhibits apamin- dependent calcium- activated potassium channels of the SK / KCNN type . Maurotoxin is amidated. Maurotoxin belongs to the scorpion toxins with four disulfide bridges , but with the unusual arrangement C 1: C5, C2: C6, C3: C4 and C7: C8. Maurotoxin binds to potassium channels via a lysine at position 23.

Web links

MeSH maurotoxin

Individual evidence

↑ Glenn F. King: Venoms to Drugs. Royal Society of Chemistry, 2015, ISBN 978-1-849-73787-6 , p. 69.
↑ Z. Fajloun, N. Andreotti, M. Fathallah, JM Sabatier, M. De Waard: Analysis of the interacting surface of maurotoxin with the voltage-gated Shaker BK (+) channel. In: Journal of peptide science: an official publication of the European Peptide Society. Volume 17, Number 3, March 2011, pp. 200-210, doi : 10.1002 / psc.1313 , PMID 21308876 .
↑ E. Carlier, V. Avdonin, S. Geib, Z. Fajloun, R. Kharrat, H. Rochat, JM Sabatier, T. Hoshi, M. De Waard: Effect of maurotoxin, a four disulfide-bridged toxin from the chactoid scorpion Scorpio maurus, on Shaker K + channels. In: The journal of peptide research: official journal of the American Peptide Society. Vol. 55, Number 6, June 2000, pp. 419-427, PMID 10888198 .

[King-1] Glenn F. King: Venoms to Drugs. Royal Society of Chemistry, 2015, ISBN 978-1-849-73787-6 , p. 69.

[2] Z. Fajloun, N. Andreotti, M. Fathallah, JM Sabatier, M. De Waard: Analysis of the interacting surface of maurotoxin with the voltage-gated Shaker BK (+) channel. In: Journal of peptide science: an official publication of the European Peptide Society. Volume 17, Number 3, March 2011, pp. 200-210, doi : 10.1002 / psc.1313 , PMID 21308876 .

[3] E. Carlier, V. Avdonin, S. Geib, Z. Fajloun, R. Kharrat, H. Rochat, JM Sabatier, T. Hoshi, M. De Waard: Effect of maurotoxin, a four disulfide-bridged toxin from the chactoid scorpion Scorpio maurus, on Shaker K + channels. In: The journal of peptide research: official journal of the American Peptide Society. Vol. 55, Number 6, June 2000, pp. 419-427, PMID 10888198 .