Membrane cofactor protein
| Membrane cofactor protein | ||
|---|---|---|
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| according to PDB 1CKL | ||
| other names |
TLX, trophoblast leukocyte common antigen, CD46, membrane cofactor protein, MCP |
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| Properties of human protein | ||
| Mass / length primary structure | 392 amino acids , 43,747 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 5788 | |
| Ensemble | ENSG00000081237 | |
| UniProt | P15529 | |
| Refseq (mRNA) | NM_001267798.1 | |
| Refseq (protein) | NP_001254727.1 | |
| PubMed search |
5788
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The membrane cofactor protein (synonymous CD46 ) is a surface protein .
properties
CD46 is produced by all cell types except erythrocytes . It is a cofactor for complement factor I in the complement system . CD46 is involved in the development of T cells into T reg1 . It is glycosylated and phosphorylated . CD46 is the cellular receptor for adenoviruses of subgroup B2 and Ad3, for measles virus and human herpes virus 6 . Presumably it is also a receptor for the cell entry of Neisseria and Streptococcus pyogenes .
Web links
Individual evidence
- ↑ MK Liszewski, JP Atkinson: Complement regulator CD46: genetic variants and disease associations. In: Human genomics. Volume 9, June 2015, p. 7, doi : 10.1186 / s40246-015-0029-z , PMID 26054645 , PMC 4469999 (free full text).