Michel C. Nut branch

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Michel C. Nussenzweig, 2015

Michel Claudio Nussenzweig (born February 10, 1955 in São Paulo ) is a Brazilian doctor (infectious diseases, immunology ).

Nussenzweig is the son of the biomedical scientists Ruth Sonntag Nussenzweig and Victor Nussenzweig . He graduated from New York University with a bachelor's degree in 1976. He received his PhD from Rockefeller University in 1981 and received his MD from New York University Medical School in 1982. He then completed specialist training in infection medicine at Massachusetts General Hospital and was a postdoctoral fellow with Philip Leder at Harvard Medical School . In 1990 he became an assistant professor at Rockefeller University, where he became professor of immunology in 1996. Since 1990 he has also been doing research for the Howard Hughes Medical Institute .

He found broadly neutralizing anti-HIV antibodies and realized that they could provide an effective immunotherapeutic against HIV . HIV-neutralizing antibodies had previously been found in macaques that escaped an outbreak of the disease, but a corresponding vaccination approach in humans was not successful. Nussenzweig found ways to clone antibody genes from B cells and applied that to antibodies against HIV. As a result, it was possible to find highly effective antibodies against HIV-1 and its strains, which are characterized by a high mutation rate. The antibodies were successfully tested in phase I clinical trials .

In his doctoral thesis with Ralph M. Steinman , he found that dendritic cells are antigen-presenting.

In 2016 he received the Robert Koch Prize . He is a member of the American Academy of Arts and Sciences (2007), the National Academy of Sciences , the Institute of Medicine of the National Academy of Sciences and a corresponding member of the Academia Brasileira de Ciências .

Fonts (selection)

  • with M. Caskey u. a .: Viremia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature 522: 487-491 (2015).
  • with LB Cohn u. a .: HIV-1 integration landscape during latent and active infection. Cell 160, 420-432 (2015)
  • with AD Gitlin a. a .: Clonal selection in the germinal center by regulated proliferation and hypermutation. Nature 509: 637-640 (2014).
  • with Z. Shulman et al. a .: Dynamic signaling by T follicular helper cells during germinal center B cell selection. Science 345: 1058-1062 (2014).
  • with A. Halper-Stromberg a. a .: Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice. Cell 158: 989-999 (2014).

Web links

Individual evidence

  1. ↑ Michele Cantazaro: A Fresh Start, Back in Brazil, at 85. In: Science , June 25, 2013.
  2. ↑ Michel Claudio Nussenzweig. In: website of the ABC. Retrieved October 28, 2019 .
personal data
SURNAME Nut branch, Michel C.
ALTERNATIVE NAMES Nut branch, Michel Claudio; Nut branch, MC
BRIEF DESCRIPTION Brazilian medic
DATE OF BIRTH February 10, 1955
PLACE OF BIRTH São Paulo