Ralph M. Steinman
Ralph Marvin Steinman (born January 14, 1943 in Montreal , † September 30, 2011 in New York City ) was a Canadian immunologist and professor at Rockefeller University in New York City. In 2011 Steinman was posthumously awarded the Nobel Prize in Physiology or Medicine , together with Bruce Beutler and Jules Hoffmann .
Life
Steinman in 1963 gained a Bachelor at McGill University in Montreal and in 1968 completed his medical studies at Harvard University in Cambridge , Massachusetts with the MD from. He then worked as a doctor at the Massachusetts General Hospital in Boston , Massachusetts before he was appointed professor ( assistant professor 1970, associate professor 1976) in leukemia research at Rockefeller University in New York City . From 1988 he was full professor of cell physiology and immunology there . Since 1998 he has also headed the Christopher Browne Center for Immunology and Immune Diseases .
In 2011 Steinman was awarded the Nobel Prize in Physiology or Medicine together with Bruce Beutler and Jules Hoffmann . His discovery of dendritic cells and their role in adaptive immunity was recognized. Steinman died three days before the award ceremony was announced of a cancer diagnosed four years earlier, without the award committee being aware of his death. He received the award posthumously , which was presented to his widow Claudia Steinman on his behalf.
Ralph Steinman was married and had two daughters and a son.
Act
Steinman and Zanvil A. Cohn discovered dendritic cells in 1973 and subsequently described them as a central and often triggering element of the immune response , especially through the activation of T cells, due to their ability to present antigens . But dendritic cells also play an important role in immune tolerance and disease resistance . In numerous papers, Steinman and co-workers analyzed the dendritic cell system, their role in the immune response and in various diseases, including transplant rejection , autoimmune diseases and infectious diseases including AIDS . The work formed the basis for further research on vaccinations and autoimmune diseases, as well as cancer immunotherapy .
Steinman was the editor of the Journal of Experimental Medicine . He has held positions on the scientific advisory board of numerous other specialist journals (including the Proceedings of the National Academy of Sciences ) and scientific societies.
Awards (selection)
- 1996: Emil von Behring Prize
- 1998: Max Planck Research Award
- 1998: William B. Coley Award
- 1999: Robert Koch Prize
- 2001: Membership in the National Academy of Sciences
- 2003: Gairdner Foundation International Award
- 2005: Membership in the Royal Society of Edinburgh
- 2006: Debrecen Prize for Molecular Medicine
- 2006: Membership in the New York Academy of Sciences
- 2007: Albert Lasker Award for Basic Medical Research
- 2009: Albany Medical Center Prize
- 2010: AH Heineken Prize for Medicine
- 2011: Nobel Prize in Physiology or Medicine (posthumous)
literature
- William Grimes: Ralph M. Steinman, a Nobel Recipient for Research on Immunology, Dies at 68 . In: The New York Times , October 4, 2011.
- Michel C. Nussenzweig : Ralph Steinman (1943–2011). In: Nature , Volume 478, 2011, p. 460, doi: 10.1038 / 478460a
- Ira Mellman, Michel Nussenzweig: Ralph M. Steinman (1943–2011). In: Science , Volume 334, 2011, p. 466, doi: 10.1126 / science.1215136
- Daniel Engber: Is the Cure for Cancer Inside You? In: The New York Times , December 21, 2012.
- Heinrich Zankl : Ralph Steinman - fighter against one's own cancer . In: Zankl H., Betz K .: Still brilliant . Wiley-VCH. Weinheim 2014. pp. 181–186. ISBN 978-3-527-33410-0
Web links
- Ralph M. Steinman, MD at rockefeller.edu
Individual evidence
- ↑ a b The Rockefeller University: Rockefeller University scientist Ralph Steinman, honored today with Nobel Prize for discovery of dendritic cells, dies at 68 . October 3, 2011.
- ↑ Lawrence K. Altman, Nicholas Wade: One of 3 Chosen for Nobel in Medicine Died Days Ago . In: The New York Times , October 3, 2011.
- ↑ a b The Nobel Prize in Physiology or Medicine 2011 at nobelprize.org, October 3, 2011 (English; accessed October 3, 2011).
- ↑ Ralph Steinman Remains Nobel Laureate at nobelprize.org (English; accessed October 3, 2011)
- ^ William Grimes: Ralph M. Steinman, a Nobel Recipient for Research on Immunology, Dies at 68 . In: The New York Times , October 4, 2011.
- ^ Emil von Behring Prize of the Philipps University of Marburg at uni-marburg.de; Retrieved October 5, 2012
- ↑ Max Planck Research Prize Winner 1998 at mpg.de ( Memento from August 15, 2009 in the Internet Archive )
- ^ William B. Coley Award. In: cancerresearch.org. Retrieved January 24, 2016 .
- ^ Winner of the Robert Koch Prize since 1970 at robert-koch-stiftung.de; Retrieved November 27, 2010
- ^ Ralph Steinman MD at the Gairdner Foundation ; Retrieved December 14, 2012
- ^ Albert Lasker Basic Medical Research Award 2010 Winners at laskerfoundation.org; Retrieved November 27, 2010
- ^ Albany Medical College: 2009. In: amc.edu. March 2011, accessed on January 23, 2016 .
- ↑ Ralph Steinman at knaw.nl; accessed on May 9, 2019.
| personal data | |
|---|---|
| SURNAME | Steinman, Ralph M. |
| ALTERNATIVE NAMES | Steinman, Ralph; Steinman, Ralph Marvin |
| BRIEF DESCRIPTION | Canadian immunologist and Nobel Prize winner |
| DATE OF BIRTH | January 14, 1943 |
| PLACE OF BIRTH | Montreal |
| DATE OF DEATH | September 30, 2011 |
| Place of death | New York City |