Gregg L. Semenza

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Gregg Leonard Semenza (* 1956 in Flushing , Queens , New York City ) is an American pediatrician and professor at Johns Hopkins University in Baltimore , Maryland . He was awarded the 2019 Nobel Prize in Medicine .

Life

Gregg L. Semenza earned a BA from Harvard University in Cambridge , Massachusetts in 1978 , an MD in 1982 and a Ph.D. in 1984. at the University of Pennsylvania in Philadelphia , Pennsylvania . He worked as an intern at Duke University Medical Center in Durham , North Carolina . As a postdoctoral fellow, he worked in human genetics at Johns Hopkins University in Baltimore , Maryland . He has been a member of the teaching staff there since 1990 and is today (as of 2011) professor at the Department of Pediatrics, Internal Medicine, Oncology and Radiation Therapy.

Semenza was able to show that cells can use the hypoxia-induced factor (HIF) to adapt to changing qualities of oxygen supply. HIF-1 regulates the transcription of genes involved in glycolysis , red blood cell production, and angiogenesis . His work has stimulated numerous fields of research, including vascular biology, the study of metabolic self-regulation and cancer research .

Nobel Prize in Physiology / Medicine 2019: Cellular Adaptation to the Availability of Oxygen Using Hif

Semenza has an h-index of 171 (as of October 2019).

Awards (selection)

Fonts (selection)

  • with MK Nejfelt, SM Chi, SE Antonarakis: Hypoxia-inducible nuclear factors bind to an enhancer element located 3 'to the human erythropoietin gene , Proc Nat. Acad. Sci. USA, Vol. 88, 1991, pp. 5680-5684
  • mit GL Wang: A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation , Mol. Cell. Biol., Vol. 12, 1992, pp. 5447-5454
  • with GL Wang, BH Jiang, EA Rue: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension , Proc. Natl. Acad. Sci. USA, Vol. 92, 1995, pp. 5510-5514.
  • Targeting HIF-1 for cancer therapy , Nat. Rev. Cancer, Vol. 3, 2003, pp. 721-732
  • with JA Forsythe, BH Jiang, NV Iyer, F. Agani, SW Leung, RD Koos: Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 , Mol. Cell. Biol., Vol. 16, 1996, pp. 4604-4613
  • with H. Zhong, AM De Marzo, E. Laughner, M. Lim, DA Hilton, D. Zagzag, P. Buechler, WB Isaacs, JW Simons: Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases , Cancer Res., Vol. 59, 1999, pp. 5830-5835
  • with others: Hypoxia-inducible factors in physiology and medicine, Cell, Volume 148, 2012, pp. 399-408

Web links

Individual evidence

  1. ↑ Farooq Ahmed: Profile of Gregg L. Semenza. In: Proceedings of the National Academy of Sciences. 107, 2010, p. 14521, doi: 10.1073 / pnas.1009481107 .
  2. ↑ Dr. Gregg L. Semenza M'82 Gr'84 on upenn.edu , accessed November 19, 2012
  3. ^ Gregg L. Semenza - Google Scholar Citations. In: scholar.google.com. Retrieved October 7, 2019 .
  4. ^ E. Mead Johnson Award - Past Recipients. In: aps-spr.org. Retrieved February 5, 2016 .
  5. ↑ Audrey Huang and Amy Cowles: Two From JHU Elected to National Academy of Sciences. The JHU Gazette May 5, 2008 at jhu.edu; Retrieved May 16, 2011
  6. ^ Gregg L. Semenza - Gairdner Foundation. In: gairdner.org. Retrieved April 13, 2018 .
  7. ^ Paul C. Webster: The winners of the 2010 Gairdner Awards. The Lancet , Volume 375, Issue 9722, Page 1239, April 10, 2010 doi: 10.1016 / S0140-6736 (10) 60526-0
personal data
SURNAME Semenza, Gregg L.
ALTERNATIVE NAMES Semenza, Gregg Leonard (full name)
BRIEF DESCRIPTION American pediatrician
DATE OF BIRTH 1956
PLACE OF BIRTH Flushing , Queens , New York City